| Type | Description |
|---|---|
| Definition | ring finger protein 19A, RBR E3 ubiquitin protein ligase |
| Date | Results | Publications |
|---|---|---|
| 2012-09-08 11:47:00 | A more than 2-fold higher level of RNF19A mRNA in the blood of patients with prostate cancer than in healthy controls makes it an early diagnosis marker for this disease. | 22493721 |
| 2010-01-21 00:00:00 | Reducing the accumulation of mutant superoxide dismutase 1 [SOD1] in the mitochondria may be a new therapeutic strategy for mutant SOD1-associated familial amyotrophic lateral sclerosis, and Dorfin may play a significant role in this | 15030390 |
| 2010-01-21 00:00:00 | results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 | 12750386 |
| 2010-01-21 00:00:00 | Dorfin-CHIP(L) rescued neuronal cells from mutant SOD1-associated toxicity and reduced the aggresome formation induced by mutant SOD1 more effectively than did Dorfin(WT). | 17157513 |
| 2010-01-21 00:00:00 | Dorfin has a role in ubiquitylating mutant SOD1 proteins and targeting them for proteasomal degradation | 12145308 |
| Type | IDs |
|---|---|
| Synonymous | RNF19 |
| Gene |
UniProtKB-ID:
RN19A_HUMAN
UniprotKB:
Q9NV58
UniParc:
UPI00015D777A,
UPI0000E44580,
UPI000013D5E6
EMBL:
BC093940,
BC093938,
AK027070,
AB271914,
AL122096,
AK023455,
AB029316,
AK001774,
AL110253,
AJ242975
Ensembl:
ENSG00000034677
KO:
hsa:25897
|
| Nucleutide sequences |
EMBL-CDS:
CAB45132.1,
BAB15647.1,
BAB39353.1,
AAH93940.1,
CAB53700.1,
BAF48117.1,
CAB59264.1,
BAB14581.1,
BAA91900.1,
AAH93938.1
Ensembl_TRS:
ENST00000341084,
ENST00000519449
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000428968,
ENSP00000342667
RefSeq:
NP_904355.1,
NP_001340766.1,
XP_024302887.1,
NP_001340767.1,
XP_016868792.1,
XP_024302886.1,
XP_016868793.1,
NP_001267468.1,
XP_011515258.1,
NP_056250.3,
XP_024302888.1,
XP_016868791.1
|
| Others |
UniRef100:
UniRef100_Q9NV58
UniRef90:
UniRef90_Q9NV58
UniRef50:
UniRef50_Q9NV58
UniGene:
Hs.292882
CCDS:
CCDS6286.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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