| Type | Description |
|---|---|
| Definition | EEF1A lysine methyltransferase 3 |
| Date | Results | Publications |
|---|---|---|
| 2018-07-21 11:13:00 | Results have shown that METTL21B is a protein methyltransferase that methylates both isoforms of translation elongation factor eEF1A at lysine 165. Also, further data suggests that METTL21B has an evolutionarily important role for the methylation of lysine 165 in eEF1A. | 28663172 |
| 2017-09-16 11:56:00 | The present study identifies METTL21B as the enzyme responsible for methylation of eEF1A on Lys-165 and shows that this modification is dynamic, inducible and likely of regulatory importance. | 28108655 |
| 2014-04-22 10:51:00 | The METTL21B protein is here suggested to be a protein methyltransferase, as it is shown to belong to a family of 10 human methyltransferases, some of which are shown to have lysine specific protein methyltransferase activity. | 22948820 |
| 2010-04-07 21:39:00 | Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | 20190274 |
| Type | IDs |
|---|---|
| Synonymous | FAM119B, METTL21B |
| Gene |
UniProtKB-ID:
EFMT3_HUMAN
UniprotKB:
Q96AZ1
UniParc:
UPI000035199B,
UPI000006CEB5,
UPI0000071992
EMBL:
BC099841,
AK024983,
AF455816,
BC016395,
BC103501,
AL050100
Ensembl:
ENSG00000123427
KO:
hsa:25895
|
| Nucleutide sequences |
EMBL-CDS:
AAH99841.1,
BAB15049.1,
CAB43271.2,
AAH16395.1,
AAI03502.1,
AAL66294.1
Ensembl_TRS:
ENST00000333012,
ENST00000300209
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000327425,
ENSP00000300209
RefSeq:
NP_996797.1,
NP_056248.2
|
| Others |
UniRef100:
UniRef100_Q96AZ1
UniRef90:
UniRef90_Q96AZ1
UniRef50:
UniRef50_Q96AZ1
UniGene:
Hs.632720
CCDS:
CCDS8957.1,
CCDS31848.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 28663172 |
Mol Cell Proteomics Joshua J Hamey , Beeke Wienert , Kate G R Quinlan , Marc R Wilkins |
2017-12-01 | - |
| 28108655 |
Nucleic Acids Res Jedrzej Malecki , Vinay Kumar Aileni , Angela Y Y Ho , Juliane Schwarz , Anders Moen , Vigdis Sørensen , Benedikt S Nilges , Magnus E Jakobsson , Sebastian A Leidel , Pål à Falnes |
2017-05-05 | - |
| 23349634 |
PLoS Genet. Philippe Cloutier , Mathieu Lavallée-Adam , Denis Faubert , Mathieu Blanchette , Benoit Coulombe |
2013-01-01 |
PGK1,
SEC53,
NNT1,
FUN12,
CDC48,
MPM1,
HUWE1,
LRPPRC,
PDIA6,
DNAJA2,
TUBB3,
TUBB4A,
PPIH,
PFDN6,
CARM1,
IPO7,
CCT7,
CCT4,
CCT2,
CCT6B,
CCT8,
HSPH1,
TUBGCP2,
RUVBL2,
STIP1,
EXOSC8,
METTL23,
HIST2H3C,
CSTA,
CTSB,
METTL21A,
DYNC1H1,
EEF2,
EEF2KMT,
METTL21C,
FOXK1,
ALDOA,
HSPA4L,
KIN,
CCT5,
KDM1A,
GANAB,
EXOSC2,
CASP14,
HSPBP1,
ETFBKMT,
METTL21B,
TIPRL,
EIF3K,
HEXB,
ANXA6,
DNAJA1,
HSPA1A,
HSPA1B,
HSPA1L,
HSPA2,
HSPA4,
HSPA5,
HSPA7,
HSPA8,
HSPA9,
HSP90AA1,
HSP90AB1,
HSPD1,
IARS,
IGBP1,
TUBB8,
TUBB2B,
HSP90AB2P,
LAMP2,
LDHA,
LDHB,
MAT2A,
MDH2,
METTL1,
EXOSC1,
DNAJB11,
PFDN1,
PFDN2,
PFDN4,
PFDN5,
POLR2H,
PRMT6,
FAM86C1,
PPP6C,
RNF126,
CCDC88A,
UGGT2,
SAR1A,
UGGT1,
CCAR2,
RARS,
RPL3,
S100A7,
S100A9,
TUBBP5,
HNRNPCL3,
FAM86B2,
SNRPA1
|
| 22948820 |
Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nat Commun Stefan Kernstock , Erna Davydova , Magnus Jakobsson , Anders Moen , Solveig Pettersen , Gunhild M Mælandsmo , Wolfgang Egge-Jacobsen , Pål à Falnes |
2012-01-01 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 20190274 |
Hum. Mol. Genet. Kaushal S Gandhi , Fiona C McKay , Mathew Cox , Carlos Riveros , Nicola Armstrong , Robert N Heard , Steve Vucic , David W Williams , Jim Stankovich , Matthew Brown , Patrick Danoy , Graeme J Stewart , Simon Broadley , Pablo Moscato , Jeannette Lechner-Scott , Rodney J Scott , David R Booth , ANZgene Multiple Sclerosis Genetics Consortium |
2010-06-01 |
Cd40,
METTL21B,
CD40
|
| 19322201 |
Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J Kotb Abdelmohsen , Subramanya Srikantan , Xiaoling Yang , Ashish Lal , Hyeon Ho Kim , Yuki Kuwano , Stefanie Galban , Kevin G Becker , Davida Kamara , Rafael de Cabo , Myriam Gorospe |
2009-05-06 | - |
| 16381901 |
Nucleic Acids Res. Alexander Mehrle , Heiko Rosenfelder , Ingo Schupp , Coral del Val , Dorit Arlt , Florian Hahne , Stephanie Bechtel , Jeremy Simpson , Oliver Hofmann , Winston Hide , Karl-Heinz Glatting , Wolfgang Huber , Rainer Pepperkok , Annemarie Poustka , Stefan Wiemann |
2006-01-01 |
AKT3,
ZBTB33,
CMC4,
DNAJB6,
C16orf95,
KIF20A,
ACTR1A,
BCAP31,
FARP1,
LPCAT3,
CDK2,
CDK7,
COQ7,
SPRY2,
STAM2,
CDKN1A,
CDKN1B,
PAK4,
CDKN2B,
RACK1,
IFITM3,
TADA3,
SEMA4F,
SORBS1,
CDC42EP3,
PDLIM5,
ATP5L,
GNB5,
CETN2,
NUDC,
CTSC,
RUVBL2,
SPIN1,
YWHAQ,
ASCC3,
MAPRE2,
SLC38A3,
NUDT21,
C10orf10,
TRIOBP,
PRSS23,
CDC37,
C14orf1,
FAM107A,
POLI,
TREX2,
EGLN2,
USP18,
CHRM2,
COPE,
GABARAPL2,
SYNPO,
ZBED9,
OSBPL5,
GPRASP2,
FCHO2,
DHRS1,
LRRC58,
LYSMD3,
LRRC3B,
RAB39B,
MIA2,
SSX2IP,
GALNT15,
CLCN3,
PIK3AP1,
MORN4,
CLIC2,
TC2N,
ZG16B,
MOB3A,
C19orf47,
LRRC39,
TMEM150A,
BBS5,
PLEKHH2,
OSR1,
COPB1,
SYNPR,
TMPRSS11B,
NUDCD2,
NCOA7,
ZNF786,
MTPN,
ZNF572,
ABRA,
PASD1,
RNF32,
MROH8,
RPL10L,
SRXN1,
CRYAB,
MIB2,
FAM76B,
ZNF664,
CPNE8,
SLFN13,
SCGB1C1,
ZNF555
|
| 15489336 |
From ORFeome to biology: a functional genomics pipeline. Genome Res. Stefan Wiemann , Dorit Arlt , Wolfgang Huber , Ruth Wellenreuther , Simone Schleeger , Alexander Mehrle , Stephanie Bechtel , Mamatha Sauermann , Ulrike Korf , Rainer Pepperkok , Holger Sültmann , Annemarie Poustka |
2004-10-01 |
AKT3,
ZBTB33,
CMC4,
DNAJB6,
C16orf95,
KIF20A,
ACTR1A,
BCAP31,
FARP1,
LPCAT3,
CDK2,
CDK7,
COQ7,
SPRY2,
STAM2,
CDKN1A,
CDKN1B,
PAK4,
CDKN2B,
RACK1,
IFITM3,
TADA3,
SEMA4F,
SORBS1,
CDC42EP3,
PDLIM5,
ATP5L,
GNB5,
CETN2,
NUDC,
CTSC,
RUVBL2,
SPIN1,
YWHAQ,
ASCC3,
MAPRE2,
SLC38A3,
NUDT21,
C10orf10,
TRIOBP,
PRSS23,
CDC37,
C14orf1,
FAM107A,
POLI,
TREX2,
EGLN2,
USP18,
CHRM2,
COPE,
GABARAPL2,
SYNPO,
ZBED9,
OSBPL5,
GPRASP2,
FCHO2,
DHRS1,
LRRC58,
LYSMD3,
LRRC3B,
RAB39B,
MIA2,
SSX2IP,
GALNT15,
CLCN3,
PIK3AP1,
MORN4,
CLIC2,
TC2N,
ZG16B,
MOB3A,
C19orf47,
LRRC39,
TMEM150A,
BBS5,
PLEKHH2,
OSR1,
COPB1,
SYNPR,
TMPRSS11B,
NUDCD2,
NCOA7,
ZNF786,
MTPN,
ZNF572,
ABRA,
PASD1,
RNF32,
MROH8,
RPL10L,
SRXN1,
CRYAB,
MIB2,
FAM76B,
ZNF664,
CPNE8,
SLFN13,
SCGB1C1,
ZNF555
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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