| Type | Description |
|---|---|
| Definition | protein kinase D2 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-29 12:44:00 | High PKD2 predicts poor prognosis in lung adenocarcinoma via promoting Epithelial-mesenchymal Transition. | 30718593 |
| 2020-03-28 10:10:00 | PKD2 and PKD3 were the two major isoforms of PKD overexpressed in breast cancer. Suppressing either PKD2 or PKD3 was able to reduce breast cancer cell proliferation and metastasis. | 30652415 |
| 2020-01-25 10:18:00 | Our findings demonstrate that recurrent and high-grade salivary gland polymorphous adenocarcinomas are underpinned by PRKD1 E710D hotspot mutations or PRKD2 rearrangements | 30843621 |
| 2019-09-28 10:52:00 | Study identified, for the first time, a functional crosstalk between protein kinase D2 (PKD2) and Aurora A kinase in cancer cells. The data demonstrate that PKD2 is catalytically active during the G2-M phases of the cell cycle, and inactivation or depletion of PKD2 causes delay in mitotic entry due to downregulation of Aurora A, an effect that can be rescued by overexpression of Aurora A. | 30018032 |
| 2019-06-22 11:56:00 | exogenous SCF, CCL5 and CCL11 reversed the effect on MCs migration inhibited by PKD2/3 silencing. Mechanistically, PKD2/3 interacted with Erk1/2 and activated Erk1/2 or NF-kappaB signaling pathway, leading to AP-1 or NF-kappaB binding to the promoter of scf, ccl5 and ccl11. | 30841931 |
| Type | IDs |
|---|---|
| Synonymous | HSPC187, PKD2, nPKC-D2 |
| Gene |
UniProtKB-ID:
KPCD2_HUMAN
UniprotKB:
Q9BZL6
UniParc:
UPI0000049BFA,
UPI00017A7E3F,
UPI000006CE36
EMBL:
AK300339,
AK074673,
KC877745,
AC093503,
AF309082,
AC008635,
AF151021,
AL050147,
AK095884
Ensembl:
ENSG00000105287
KO:
hsa:25865
|
| Nucleutide sequences |
EMBL-CDS:
BAG62084.1,
BAC11127.1,
BAG53158.1,
CAB43292.1,
AAK01149.1,
AAF36107.1
Gene_ORFName:
HSPC187
Ensembl_TRS:
ENST00000291281,
ENST00000601806,
ENST00000600194,
ENST00000433867,
ENST00000595515
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000291281,
ENSP00000472744,
ENSP00000393978,
ENSP00000469106,
ENSP00000470804
RefSeq:
NP_057541.2,
NP_001073350.1,
NP_001073349.1,
NP_001073351.1,
XP_005258773.2
|
| Others |
UniRef100:
UniRef100_Q9BZL6
UniRef90:
UniRef90_Q9BZL6
UniRef50:
UniRef50_Q9BZL6
UniGene:
Hs.466987
CCDS:
CCDS59401.1,
CCDS12689.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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