| Type | Description |
|---|---|
| Definition | anti-silencing function 1A histone chaperone |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:23:00 | In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma. | 31744829 |
| 2020-01-25 14:06:00 | We demonstrate that the CIA-targeting complex promotes the ability of FBXL5 to degrade iron regulatory proteins. In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation | 31229404 |
| 2019-12-14 12:01:00 | ASF1A regulated H4(Y72ph) and promotes autophagy in colon cancer cells via a kinase activity through regulation of ATG | 31286799 |
| 2019-11-16 10:23:00 | ASF1A depletion leads to increased recruitment of DNA-PKcs to DSBs. | 29954236 |
| 2019-01-12 11:25:00 | faithful transmission of histone variants involves ASF1 and can be impacted by replication stress, with ensuing consequences for cell fate and tumorigenesis | 30093638 |
| Type | IDs |
|---|---|
| Synonymous | CGI-98, CIA, HSPC146 |
| Gene |
UniProtKB-ID:
ASF1A_HUMAN
UniprotKB:
Q9Y294
UniParc:
UPI000004CF64
EMBL:
AF161495,
CR457347,
AK025738,
AC022098,
BC010878,
AF151856,
AF279306,
AB028628,
AL050261
Ensembl:
ENSG00000111875
KO:
hsa:25842
|
| Nucleutide sequences |
EMBL-CDS:
BAA96542.1,
AAK82972.1,
CAB43363.1,
AAD34093.1,
BAB15228.1,
AAF29110.1,
CAG33628.1,
AAH10878.1
Gene_ORFName:
HSPC146,
CGI-98
Ensembl_TRS:
ENST00000229595
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000229595
RefSeq:
NP_054753.1
|
| Others |
UniRef100:
UniRef100_Q9Y294
UniRef90:
UniRef90_Q9Y294
UniRef50:
UniRef50_Q9Y294
UniGene:
Hs.292316
CCDS:
CCDS47469.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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