| Type | Description |
|---|---|
| Definition | sulfotransferase family 4A member 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 11:31:00 | Study in SULT4A1 knockout mice demonstrates that depletion of SULT4A1 induces oxidative stress in neurons and expression of SULT4A1 in human SH-SY5Y cells protects against oxidative-stress-induced mitochondrial dysfunction and cell death. Results suggest that SULT4A1 may have a crucial protective function against mitochondrial dysfunction and oxidative stress. | 31266751 |
| 2019-08-31 12:19:00 | Study using SH-SY5Y cells, human induced pluripotent stem cells, and mouse embryonic tissue revealed time-dependent changes in SULT4A1 protein and MBNL/CELF protein during differentiation supported their role in correctly splicing the SULT4A1 mRNA. Furthermore, ectopic expression of each factor produced efficient splicing in the minigene assay as well as correct splicing of the endogenous SULT4A1 mRNA. | 30606728 |
| 2015-10-24 10:18:00 | These results show that SULT4A1 is widely expressed in human tissues, but mostly as a splice variant that produces a rapidly degraded protein. Dimerization protects the protein from degradation. | 24988429 |
| 2015-07-04 15:24:00 | Across three psychiatric disorders (n=2815 patients), we observed no consistent association between SULT4A1-1 status and atypical antipsychotic effect | 25340730 |
| 2015-02-14 12:07:00 | This study provides a second replication of superior olanzapine response in SULT4A1-1-positive subjects compared with SULT4A1-1-negative subjects. | 24956247 |
| Type | IDs |
|---|---|
| Synonymous | BR-STL-1, BRSTL1, DJ388M5.3, NST, SULTX3, hBR-STL-1 |
| Gene |
UniProtKB-ID:
ST4A1_HUMAN,
B7Z2E1_HUMAN
UniprotKB:
Q9BR01,
B7Z2E1
UniParc:
UPI0000135477,
UPI000047F817,
UPI000002B32D
EMBL:
AF251263,
AF188698,
AK313048,
Z97055,
BC028171,
BC022459,
AF115311,
AF176342,
CH471138,
AK294622,
AL590119,
CR456588,
BC030665
Ensembl:
ENSG00000130540
KO:
hsa:25830
|
| Nucleutide sequences |
EMBL-CDS:
AAF98152.1,
AAK64595.1,
BAG35880.1,
CAG30474.1,
AAH22459.1,
EAW73320.1,
CAC34872.1,
AAH28171.1,
AAH30665.1,
AAF21970.1,
AAF61197.1,
BAH11827.1
Ensembl_TRS:
ENST00000422525,
ENST00000330884
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000388285,
ENSP00000332565
RefSeq:
NP_055166.1,
XP_011528423.1,
XP_011528422.1,
XP_024307980.1
|
| Others |
UniRef100:
UniRef100_Q9BR01,
UniRef100_B7Z2E1
UniRef90:
UniRef90_Q9BR01,
UniRef90_A0A3Q2UFV3
UniRef50:
UniRef50_Q9BR01,
UniRef50_A0A3Q2UFV3
UniGene:
Hs.189810
CCDS:
CCDS14051.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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