| Type | Description |
|---|---|
| Definition | beta-secretase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:45:00 | RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation. | 32566665 |
| 2021-02-06 13:49:00 | TGFbeta1-induced beta-site APP-cleaving enzyme 2 upregulation promotes tumorigenesis through the NF-kappaB signalling pathway in human gliomas. | 31856384 |
| 2020-11-21 13:34:00 | BACE2 degradation is mediated by both the proteasome and lysosome pathways. | 32160867 |
| 2020-10-24 14:02:00 | Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer's Disease and CSF Amyloid Biomarkers in APOE epsilon4 Non-Carriers. | 31270419 |
| 2017-04-08 12:15:00 | the behavior of the flap tips during simulations is different between BACE1 and BACE2. The BACE1 active site cavity is more spacious as compared to that of BACE2. The analysis of 10S loop and 113S loop showed a similar trend to that of flaps, with the BACE1 loops being more flexible and less stable than those of BACE2 | 26804314 |
| Type | IDs |
|---|---|
| Synonymous | AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP |
| Gene |
UniProtKB-ID:
BACE2_HUMAN
UniprotKB:
Q9Y5Z0
UniParc:
UPI0000070338,
UPI0000073962,
UPI000044CA62,
UPI00000396BC,
UPI00001612A9
EMBL:
AK292056,
AL163285,
BC014453,
AF200342,
AK075539,
AF212252,
AF188276,
AF200192,
AF117892,
AF178532,
AF188277,
AL163284,
AY358927,
AF050171,
CH471079,
AY769996,
AF204944
Ensembl:
ENSG00000182240
KO:
hsa:25825
|
| Nucleutide sequences |
EMBL-CDS:
AAF35835.1,
CAB90554.1,
CAB90458.1,
AAD45240.1,
AAF13714.1,
AAX14808.1,
AAF26368.1,
AAD45963.1,
BAF84745.1,
AAF35836.1,
EAX09611.1,
AAF29494.1,
AAG41783.1,
AAH14453.1,
AAF17078.1,
BAC11682.1,
EAX09613.1,
AAQ89286.1
Gene_ORFName:
UNQ418/PRO852,
CDA13
Ensembl_TRS:
ENST00000347667,
ENST00000330333,
ENST00000328735
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000327528,
ENSP00000332979,
ENSP00000333854
RefSeq:
NP_036237.2,
NP_620477.1,
XP_016883803.1,
NP_620476.1
|
| Others |
UniRef100:
UniRef100_Q9Y5Z0
UniRef90:
UniRef90_Q9Y5Z0
UniRef50:
UniRef50_Q9Y5Z0
UniGene:
Hs.43047,
Hs.529408
CCDS:
CCDS13670.1,
CCDS13668.1,
CCDS13669.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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