| Type | Description |
|---|---|
| Definition | mitochondrial tRNA translation optimization 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-15 19:03:00 | CircMTO1 inhibits liver fibrosis via regulation of miR-17-5p and Smad7. | 31148365 |
| 2019-03-09 11:38:00 | Low MTO1 expression is associated with Mitochondrial diseases in neoplasms. | 28740091 |
| 2018-12-29 11:30:00 | Two novel variants (c.[253G > A];[938G > A]) in the MTO1 gene were identified in a child with cardiomyopathy with early-onset brain disease. | 29440775 |
| 2018-12-22 10:25:00 | MTO1 deficiency is lethal in some but not all cases, and a genotype-phenotype relation is suggested. Aside from lactic acidosis and cardiomyopathy, developmental delay and other phenotypic features affecting multiple organ systems are often present in these patients, suggesting a broader spectrum than hitherto reported. | 29331171 |
| 2018-11-24 12:06:00 | Defects in the mitochondrial tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARgamma-UCP2-AMPK axis. | 29348686 |
| Type | IDs |
|---|---|
| Synonymous | CGI-02, COXPD10 |
| Gene |
UniProtKB-ID:
MTO1_HUMAN
UniprotKB:
Q9Y2Z2
UniParc:
UPI0001639C21,
UPI000002AE74,
UPI000002AE72,
UPI000002AE73,
UPI000002AE75,
UPI000012F816
EMBL:
AF319422,
AF469110,
AK225828,
BC011051,
AF469111,
AK074625,
CH471051,
AY078985,
BC005808,
AY078986,
AF132937,
AL833823,
AL603910,
AF442963
Ensembl:
ENSG00000135297
KO:
hsa:25821
|
| Nucleutide sequences |
EMBL-CDS:
AAD27712.1,
BAG51977.1,
EAW48762.1,
AAL85491.1,
AAL82394.1,
AAG42814.3,
CAD38685.1,
AAL82395.1,
AAH05808.2,
AAL85490.1,
AAL35894.1,
AAH11051.2
Gene_ORFName:
CGI-02
Ensembl_TRS:
ENST00000415954,
ENST00000370300,
ENST00000370305,
ENST00000498286
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000419561,
ENSP00000359323,
ENSP00000402038,
ENSP00000359328
RefSeq:
NP_001116698.1,
NP_036255.2,
NP_598400.1
|
| Others |
UniRef100:
UniRef100_Q9Y2Z2
UniRef90:
UniRef90_Q9Y2Z2
UniRef50:
UniRef50_Q9Y2Z2
UniGene:
Hs.347614
CCDS:
CCDS34485.1,
CCDS4979.1,
CCDS47452.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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