| Type | Description |
|---|---|
| Definition | ariadne RBR E3 ubiquitin protein ligase 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-04 11:40:00 | ubiquitin-associated (UBA) domain-containing DCNL1 is monoubiquitylated when bound to CRLs and that this monoubiquitylation depends on the CRL-associated Ariadne RBR ligases TRIAD1 (ARIH2) and HHARI (ARIH1) and strictly requires the DCNL1's UBA domain. | 30587576 |
| 2018-06-09 11:21:00 | ARIH1-mediated mitophagy promotes therapeutic resistance. | 28930681 |
| 2018-06-02 12:07:00 | Variants in ARIH1 are associated with developing aortic aneurysms. | 29689197 |
| 2018-03-24 11:48:00 | Crystal structure of HHARI and UbcH7 reveals UbcH7 approximately Ub binding RING1 domain of auto-inhibited HHARI.HHARI UBA-L domain has Ub binding properties. | 28552575 |
| 2017-12-16 11:42:00 | HHARI prevents spurious discharge of Ub from E2 to lysine residues by harboring structural elements that block E2 ~ Ub from adopting a 'closed' conformation. | 28790309 |
| Type | IDs |
|---|---|
| Synonymous | ARI, HARI, HHARI, UBCH7BP |
| Gene |
UniProtKB-ID:
ARI1_HUMAN
UniprotKB:
Q9Y4X5
UniParc:
UPI0000033466
EMBL:
AC100827,
AC079322,
AK312715,
AJ009771,
AF072832,
AB014774,
BC051877,
AJ130976,
CH471082,
AJ243190
Ensembl:
ENSG00000166233
KO:
hsa:25820
|
| Nucleutide sequences |
EMBL-CDS:
BAB19786.1,
CAA08817.1,
BAG35590.1,
AAD28088.1,
AAH51877.1,
EAW77907.1,
CAA10274.1,
CAB45870.1
Gene_ORFName:
HUSSY-27
Ensembl_TRS:
ENST00000379887
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000369217
RefSeq:
NP_005735.2
|
| Others |
UniRef100:
UniRef100_Q9Y4X5
UniRef90:
UniRef90_Q9Y4X5
UniRef50:
UniRef50_Q9Y4X5
UniGene:
Hs.268787
CCDS:
CCDS10244.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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