| Type | Description |
|---|---|
| Definition | SAM pointed domain containing ETS transcription factor |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:34:00 | Assessment of mucin-related gene alterations following treatment with rebamipide ophthalmic suspension in Sjogren's syndrome-associated dry eyes. | 33232357 |
| 2020-08-01 15:23:00 | Targeting SPDEF led to proportional decreases in MUC5AC expression in human bronchial epithelial cells stimulated with IL-13. Near-complete targeting of SPDEF abolished IL-13-induced MUC5AC expression and goblet cell differentiation. Targeting of SPDEF prevented IL-13-induced impairment of mucociliary clearance. | 31596609 |
| 2019-11-23 12:49:00 | Hypermethylation of SPDEF gene locus was associated with a greater number of stressful life events in an allele-dependent way. Among individuals with the minor G-allele, SPDEF methylation moderated the association between psychosocial stress and substance abuse. SPDEF methylation interacted with lifetime stress in gray matter volume in the right cuneus, which was associated with the frequency of alcohol and tobacco use. | 30525907 |
| 2019-10-12 13:12:00 | SPDEF is overexpressed in gastric cancer and triggers cell proliferation by forming a positive regulation loop with FoxM1 | 30076647 |
| 2019-08-31 11:48:00 | This study reports the novel findings that PDEF suppresses Twist1 partly via CK18 and that PDEF/Twist1 could help distinguish between lethal and indolent prostate cancer. | 29848555 |
| Type | IDs |
|---|---|
| Synonymous | PDEF, bA375E1.3 |
| Gene |
UniProtKB-ID:
SPDEF_HUMAN
UniprotKB:
O95238
UniParc:
UPI000206552C,
UPI0000034E30
EMBL:
AB031549,
BX255972,
BX255971,
AK301543,
AF071538,
BX255973,
BC021299,
AL157372
Ensembl:
ENSG00000124664
KO:
hsa:25803
|
| Nucleutide sequences |
EMBL-CDS:
BAG63040.1,
AAH21299.1,
AAC95296.1,
CAI23605.1,
BAA89543.1
Ensembl_TRS:
ENST00000544425,
ENST00000374037
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000363149,
ENSP00000442715
RefSeq:
XP_011512759.1,
XP_005249045.2,
NP_036523.1,
NP_001239223.1
|
| Others |
UniRef100:
UniRef100_O95238
UniRef90:
UniRef90_O95238
UniRef50:
UniRef50_O95238
UniGene:
Hs.485158
CCDS:
CCDS4794.1,
CCDS59013.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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