SHC2 - SHC adaptor protein 2-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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25759 SHC2

基因描述

Type	Description
Definition	SHC adaptor protein 2

研究结论

Date	Results	Publications
2016-04-09 10:03:00	Sck was identified as a novel molecule indispensable for CD95's activation of the PI3K and MAPK pathways and induction of cell cycle progression in pancreatic ductal adenocarcinoma.	25613377
2014-10-25 10:16:00	SHC2 gene deletions underlie few, if any, cases of well-characterized multiple system atrophy in the US population.	24170347
2011-11-19 11:17:00	Data show that copy number loss of SHC2 strongly indicates a causal link to multiple system atrophy.	21658278

名称对应

Type	IDs
Synonymous	SCK, SHCB, SLI
Gene	UniProtKB-ID: SHC2_HUMAN UniprotKB: P98077 UniParc: UPI0000DD84C2 EMBL: AC006124, AB001451, AC138433, AC008988, AL360254 Ensembl: ENSG00000129946 KO: hsa:25759
Nucleutide sequences	EMBL-CDS: BAA25798.1, CAB96175.1 Ensembl_TRS: ENST00000264554
Protein sequencees	Ensembl_PRO: ENSP00000264554 RefSeq: NP_036567.2, NP_001373985.1, XP_011526195.1, XP_011526196.1, XP_011526198.1
Others	UniRef100: UniRef100_P98077 UniRef90: UniRef90_P98077 UniRef50: UniRef50_P98077 UniGene: Hs.30965 CCDS: CCDS45891.1

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
28611215	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proc. Natl. Acad. Sci. U.S.A. Teng Fei , Yiwen Chen , Tengfei Xiao , Wei Li , Laura Cato , Peng Zhang , Maura B Cotter , Michaela Bowden , Rosina T Lis , Shuang G Zhao , Qiu Wu , Felix Y Feng , Massimo Loda , Housheng Hansen He , X Shirley Liu , Myles Brown	2017-06-27	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
25613377	CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma. Cell Death Differ. M Teodorczyk , S Kleber , D Wollny , J P Sefrin , B Aykut , A Mateos , P Herhaus , I Sancho-Martinez , O Hill , C Gieffers , J Sykora , W Weichert , C Eisen , A Trumpp , M R Sprick , F Bergmann , T Welsch , A Martin-Villalba	2015-07-01	SHC2, FAS
24728074	Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. Mol Cell Proteomics Kin K Leung , Ronald J Hause , John L Barkinge , Mark F Ciaccio , Chih-Pin Chuu , Richard B Jones	2014-07-01	-
24430869	The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor. Mol. Biol. Cell Melanie K B Wills , Jiefei Tong , Sylvie L Tremblay , Michael F Moran , Nina Jones	2014-03-01	EGFR, SHC4
24170347	SHC2 gene copy number in multiple system atrophy (MSA). Clin. Auton. Res. Marcus C Ferguson , Emily M Garland , Lora Hedges , Bethany Womack-Nunley , Rizwan Hamid , John A Phillips , Cyndya A Shibao , Satish R Raj , Italo Biaggioni , David Robertson	2014-02-01	-
24189400	Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Mol. Syst. Biol. Jiannong Li , Keiryn Bennett , Alexey Stukalov , Bin Fang , Guolin Zhang , Takeshi Yoshida , Isamu Okamoto , Jae-Young Kim , Lanxi Song , Yun Bai , Xiaoning Qian , Bhupendra Rawal , Michael Schell , Florian Grebien , Georg Winter , Uwe Rix , Steven Eschrich , Jacques Colinge , John Koomen , Giulio Superti-Furga , Eric B Haura	2013-01-01	CDH3, DNAJB6, AP1M2, LRPPRC, PDIA6, CDK4, CDK9, DNAJA2, TFG, PKDREJ, TUBA1B, MYL12B, BAIAP2, DDX17, MYL12A, YWHAQ, KDELR2, CDC37, ATXN2L, PHB2, CHUK, FCHO2, AP2M1, AP2S1, CLK3, COL17A1, S100A16, HNRNPA1L2, CSTA, CTNNA1, CTNNA2, CTNNB1, CTNND1, EEF1A1P5, AP2A1, AP2A2, AP1B1, AP2B1, DDX5, DNAJB8, DHCR7, EEF1A1, EEF1A2, EGFR, CTTN, TUBB, ANO5, EPS15, ERBB2, ERBB3, ESRRB, EWSR1, ACSL3, HNRNPA3, HIST1H2AA, XRN2, PHLDA1, AAK1, MRPS27, VPS13A, FUS, SHC2, ARMC8, GAPDH, GFAP, RPS6KA6, GNB1, GNB2, GNB3, SFN, GRB2, GRB7, MRPS28, MRPS18B, TIMM21, SLC25A4, SLC25A5, SLC25A6, GSTT1, SEC61A1, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H1T, ANXA1, ANXA2, HIST1H1A, HBA1, HBB, HBD, HBE1, HBG1, HBG2, HLA-A, HLA-B, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD
22973453	Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors. PLoS ONE Ronald J Hause , Kin K Leung , John L Barkinge , Mark F Ciaccio , Chih-Pin Chuu , Richard B Jones	2012-01-01	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21658278	Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy. Mol Brain Hidenao Sasaki , Mitsuru Emi , Hiroshi Iijima , Noriko Ito , Hidenori Sato , Ichiro Yabe , Takeo Kato , Jun Utsumi , Kenichi Matsubara	2011-01-01	SHC2

研究热度

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