| Type | Description |
|---|---|
| Definition | insulin degrading enzyme |
| Date | Results | Publications |
|---|---|---|
| 2019-04-20 10:28:00 | GLP-1R regulates cell growth, at least partially, through regulating signaling pathway in ABETA(1-42)-treated PC12 cells. | 29263141 |
| 2018-11-24 11:34:00 | data suggest that insulin deprivation, rather than high glucose, is a significant determinant of IDE regulation; as evidence indicates potential roles for IDE in diabetes and Alzheimer's disease, understanding the mechanisms regulating IDE expression may be important in developing new treatment strategies | 29940507 |
| 2017-02-25 12:31:00 | This study concluded that vitamin D3 ameliorated insulin resistance and hyperinsulinemia in diabetic rat model received high fructose water through reduction of insulin-degrading enzyme and activation of insulin receptor phosphorylation. | 27930980 |
| 2016-04-16 10:37:00 | Ageing and diabetes are accompanied by a deficit of IDE in the brain structures where accumulation of Abeta was reported in Azheimer disease patients. | 25792373 |
| 2015-06-27 10:22:00 | Insulin-degrading enzyme is able to degrade specific amino acid sequences present in the neuropeptide pro-NPFFA (NPFF precursor), generating some cryptic peptides that are also observed after incubation with rat brain cortex homogenate. | 25247577 |
| Type | IDs |
|---|---|
| Synonymous | INSDEGM |
| Gene |
UniProtKB-ID:
IDE_RAT,
A0A0G2K7Q7_RAT
UniprotKB:
P35559,
A0A0G2K7Q7
UniParc:
UPI0002190210,
UPI000012D19E
EMBL:
X67269,
S53721,
AC103485
Ensembl:
ENSRNOG00000016833
KO:
rno:25700
|
| Nucleutide sequences |
EMBL-CDS:
CAA47689.1,
AAB25205.1
Ensembl_TRS:
ENSRNOT00000023342,
ENSRNOT00000085303
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000023342,
ENSRNOP00000074304
RefSeq:
XP_017444320.1,
NP_037291.1,
XP_006231375.1,
XP_008758584.1
|
| Others |
UniRef100:
UniRef100_P35559
UniRef90:
UniRef90_P14735
UniRef50:
UniRef50_P14735
UniGene:
Rn.45029
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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