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2569 GABRR1

2569

GABRR1

gamma-aminobutyric acid type A receptor rho1 subunit

protein-coding

Homo sapiens

基因描述

Type Description
Definition gamma-aminobutyric acid type A receptor rho1 subunit

研究结论

Date Results Publications
2018-06-30 11:24:00 GABAergic genes interacting with parenting in adolescent depressive symptoms: GABRR1 X perceived parental support interaction. 28660714
2018-05-12 12:12:00 Study determined that levels of GABAA receptors rho1 and rho2 are not altered in the cerebellum of WT and rho1 knockin mice. In addition, findings show that mutation of the inhibitory ethanol site in rho1 does not alter normal channel function, but is important for the development of acute tolerance to ethanol-induced motor impairment. 28623169
2018-01-27 11:08:00 The most common polymorphisms in the GABRR genes seemed to be not associated with the risk for migraine in Caucasian Spanish people, although one of them (GABRR1 rs1186902) shows a statistically significant association with the age of onset of migraine. 28699326
2017-09-02 10:41:00 Thr244 of rho1 GABAC Receptors is an important residue for channel activation as it forms a H-bond with agonists, initiating the conformational changes required for priming of the receptor and stabilizes the open conformation (review). 27244450
2016-06-04 12:10:00 Both GABAAalpha1 and GABAArho1 mRNAs and proteins were identified in cultured retinal pigment epithelial cells; antibody staining was mainly localized to the cell membrane and was also present in the cytoplasm but not in the nucleus. 26321868

名称对应

Type IDs
Gene
UniProtKB-ID: GBRR1_HUMAN
UniprotKB: P24046
UniParc: UPI00018E1810, UPI0001915525, UPI0000D4AF7D
EMBL: AK298948, AL353135, BC130344, M62400, AK296124, AL353659
Ensembl: ENSG00000146276
KO: hsa:2569
Nucleutide sequences
EMBL-CDS: BAG58870.1, AAA52509.1, AAI30345.1, BAG61047.1
Ensembl_TRS: ENST00000611484, ENST00000435811, ENST00000369451, ENST00000454853, ENST00000621627
Protein sequencees
Ensembl_PRO: ENSP00000358463, ENSP00000478846, ENSP00000481986, ENSP00000394687, ENSP00000412673
RefSeq: NP_001254511.1, NP_001243632.1, NP_002033.2, NP_001243633.1, XP_016866178.1
Others
UniRef100: UniRef100_P24046
UniRef90: UniRef90_P24046
UniRef50: UniRef50_P24046
UniGene: Hs.99927
CCDS: CCDS59029.1, CCDS5019.2, CCDS59028.1

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