| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase, non-receptor type 11 |
| Date | Results | Publications |
|---|---|---|
| 2019-04-27 10:41:00 | Shp2 inhibition ameliorated muscularization of pulmonary arterioles in MCT-induced PAH rats. Shp2 inhibition significantly reduced platelet-derived growth factor -triggered proliferation and migration of human pulmonary artery smooth muscle cells, which might be attributed to the inactivations of Akt and Stat3 pathways. | 30086741 |
| 2018-11-24 11:38:00 | the effect of SHP-2 on the proliferation, cell cycle and apoptosis of renal tubular epithelial cells was investigated. | 29991025 |
| 2018-03-10 10:29:00 | Data demonstrate that the increased activation of MAPK signaling pathway by SHP2D61G could deregulate the surface expression of synaptic receptors during neuronal development. | 28366775 |
| 2017-10-28 12:17:00 | findings demonstrate that IL-17 regulates SHP-2 expression and dependent production of Cyr61, IL-23, GM-CSF and RANKL in AA-FLS and may reveal a new insight into the pathogenesis of RA. | 28898718 |
| 2017-09-30 11:11:00 | Data suggest that phosphorylation of Shp2/Ptpn11 at Tyr542 and its translocation to postsynaptic compartment are integral processes in synaptic scaling/homeostasis; Shp2 phosphatase activity is critical to regulation of Ser(P)845 GluA1 and surface expression of GluA1 during synaptic scaling. (Shp2/Ptpn11 = protein tyrosine phosphatase non-receptor type 11; GluA1 = glutamate receptor ionotropic Ampa1 [alpha 1]) | 28768764 |
| Type | IDs |
|---|---|
| Synonymous | Shp2 |
| Gene |
UniProtKB-ID:
PTN11_RAT
UniprotKB:
P41499
UniParc:
UPI000017F37E,
UPI000013296F
EMBL:
U09307,
U05963
Ensembl:
ENSRNOG00000030124
KO:
rno:25622
|
| Nucleutide sequences |
EMBL-CDS:
AAA20543.1,
AAA19133.1
Ensembl_TRS:
ENSRNOT00000046323
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000041842
RefSeq:
NP_001171064.1,
NP_037220.2
|
| Others |
UniRef100:
UniRef100_P41499
UniRef90:
UniRef90_Q06124
UniRef50:
UniRef50_Q06124
UniGene:
Rn.98209
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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