| Type | Description |
|---|---|
| Definition | gamma-aminobutyric acid type A receptor beta3 subunit |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 12:59:00 | Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors. | 32540960 |
| 2020-07-18 10:33:00 | The intracellular domain of alpha3 and beta3 each contain essential anterograde trafficking signals that are required to overcome ER retention of assembled GABAA homo- or heteropentamers. | 31610743 |
| 2020-06-20 12:40:00 | We found that receptors containing either GABRB3 (N328D) or GABRB3 (E357K) mutant subunits had reduced GABA-evoked peak current amplitude. we found that both the GABRB3 (N328D) and GABRB3 (E357K) mutations reduced total subunit expression in neurons but not in HEK293T cells. | 31435640 |
| 2019-09-28 11:47:00 | cryo-EM structure of the human alpha5beta3 GABAA receptor | 30140029 |
| 2019-07-20 11:38:00 | Receptors containing the GABRB3 p.P301L variant were less sensitive to GABA and produced less GABA-evoked current. | 29961870 |
| Type | IDs |
|---|---|
| Synonymous | ECA5, EIEE43 |
| Gene |
UniProtKB-ID:
GBRB3_HUMAN,
B2RCW8_HUMAN,
X5DQY4_HUMAN
UniprotKB:
P28472,
B2RCW8,
X5DQY4
UniParc:
UPI0001DD21C2,
UPI000012AFB0,
UPI0000EE7554,
UPI0001750878,
UPI000002AA2A
EMBL:
EU606048,
AK295167,
AC135999,
AK302822,
L04311,
AC145167,
AC127511,
AC009878,
AC145196,
KJ534842,
AC011196,
AK315311,
AC104569,
BC010641,
M82919,
CH471151
Ensembl:
ENSG00000166206
KO:
hsa:2562
|
| Nucleutide sequences |
EMBL-CDS:
AAA52511.1,
BAH13811.1,
AAA52508.1,
AAA52507.1,
AAH10641.1,
EAW57655.1,
BAH11997.1,
BAG37715.1,
AHW56482.1
Ensembl_TRS:
ENST00000636466,
ENST00000622697,
ENST00000545868,
ENST00000400188,
ENST00000299267,
ENST00000628124,
ENST00000311550
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000489768,
ENSP00000299267,
ENSP00000383049,
ENSP00000439169,
ENSP00000486819,
ENSP00000308725,
ENSP00000481004
RefSeq:
NP_068712.1,
NP_001178249.1,
NP_000805.1,
NP_001265560.1,
NP_001178250.1,
XP_011519730.1
|
| Others |
UniRef100:
UniRef100_P28472,
UniRef100_B2RCW8,
UniRef100_P28472-2
UniRef90:
UniRef90_P28472
UniRef50:
UniRef50_P28472
UniGene:
Hs.302352,
Hs.727263
CCDS:
CCDS10018.1,
CCDS53920.1,
CCDS53921.1,
CCDS10019.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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