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25522 Prkcz

25522

Prkcz

protein kinase C, zeta

protein-coding

Rattus norvegicus

基因描述

Type Description
Definition protein kinase C, zeta

研究结论

Date Results Publications
2020-03-28 10:39:00 PKMzeta inhibition disrupts reconsolidation and erases object recognition memory. Results also indicate that hippocampal PKMzeta acts downstream of BDNF and controls AMPAR synaptic insertion to elicit reconsolidation and suggest that blocking PKMzeta activity during this process deletes active object recognition memory. 30622166
2020-02-01 11:45:00 M zeta is activated in prelimbic cortex during consolidation of memory. 31026567
2018-11-10 12:20:00 The current studies demonstrate that enhanced action potential firing produced by NGF was blocked by inhibitors of translation, but not transcription. In vitro studies showed that NGF elevated the protein levels of PKMzeta, which was also prevented by inhibitors of translation. Intraplantar injection of NGF produced a rapid and maintained increase in mechanical sensitivity whose onset was delayed by translation inhibit... 29288797
2018-10-20 11:54:00 the overexpression of PKMzeta in hippocampal neurons immobilized GluA2-containing AMPA receptors. 29202853
2018-02-24 11:12:00 Here we find that spatial conditioning by aversive active place avoidance or appetitive radial arm maze induces PKMzeta increases in dorsal hippocampus that persist from 1day to 1month, coinciding with the strength and duration of memory retention. 27417578

名称对应

Type IDs
Synonymous 14-3-3-zetaisoform, Pkcz, r14-3-3
Gene
UniProtKB-ID: KPCZ_RAT
UniprotKB: P09217
UniParc: UPI000012DF77, UPI000059E27E
EMBL: J04532, M18332
Ensembl: ENSRNOG00000015480
KO: rno:25522
Nucleutide sequences
EMBL-CDS: AAA41878.1, AAA41934.1
Ensembl_TRS: ENSRNOT00000021285
Protein sequencees
Ensembl_PRO: ENSRNOP00000021285
RefSeq: XP_008762559.1, XP_006239598.1, NP_071952.1, XP_006239597.1, XP_017448650.1
Others
UniRef100: UniRef100_P09217
UniRef90: UniRef90_P09217
UniRef50: UniRef50_P09217
UniGene: Rn.1109

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