| Type | Description |
|---|---|
| Definition | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase |
| Date | Results | Publications |
|---|---|---|
| 2020-02-08 10:42:00 | The data revealed that maternal immune activation impedes offspring's dendrite development and causes depressive like behaviors by upregulating ISG15 and suppressing NEDD4/Rap2A signaling. | 30826466 |
| 2019-06-22 11:14:00 | NEDD4, the top focus hub gene, showed a clear time-dependent increased expression pattern in cardiomyocytes during angiotensin II treatment. | 30632068 |
| 2018-03-10 11:23:00 | NEDD4-1 levels were decreased after ischemia-reperfusion (I/R) and increased after ischemic preconditioning in rat heart tissue and in H9c2 cardiomyocytes. Overexpression activated the Akt pathway and regulated apoptosis-related proteins in H9c2 cardiomyocytes, attenuating SI/R-induced cell apoptosis and caspase 3/7 activities. Overexpression attenuated myocardial apoptosis after I/R. | 27837380 |
| 2017-11-04 11:53:00 | Data suggest that dietary factors can regulate cardiac Scnn1g, Nedd4-2, and Sgk1 activity; here, proanthocyanidin dietary supplement PRO80 blocks aldosterone-dependent up-regulation of Scnn1g, Nedd4-2, and Sgk1 content in cardiac dysfunction. (Scnn1g = epithelial sodium channel 1, gamma subunit; Nedd4-2 = ubiquitin-protein ligase Nedd4-2; Sgk1 = serum-glucocorticoid regulated kinase 1) | 27592201 |
| 2016-08-20 10:14:00 | CRTC2 and Nedd4 ligase involvement in FSH and TGFbeta1 upregulation of connexin43 gap junction | 26508620 |
| Type | IDs |
|---|---|
| Synonymous | Nedd4a |
| Gene |
UniProtKB-ID:
NEDD4_RAT,
A0A0G2K8P3_RAT
UniprotKB:
Q62940,
A0A0G2K8P3
UniParc:
UPI000155184C,
UPI00000E6E70
EMBL:
CH474041,
AABR07070669,
U50842,
AABR07070668
Ensembl:
ENSRNOG00000058898
KO:
rno:25489
|
| Nucleutide sequences |
EMBL-CDS:
AAB48949.1,
EDL84129.1
Gene_ORFName:
rCG_56604
Ensembl_TRS:
ENSRNOT00000088391
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000074683
RefSeq:
NP_037118.1,
XP_017450968.1
|
| Others |
UniRef100:
UniRef100_A0A0G2K8P3,
UniRef100_Q62940
UniRef90:
UniRef90_Q62940,
UniRef90_A0A0G2K8P3
UniRef50:
UniRef50_Q62940,
UniRef50_P46935
UniGene:
Rn.99540
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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