| Type | Description |
|---|---|
| Definition | heparin-binding EGF-like growth factor |
| Date | Results | Publications |
|---|---|---|
| 2020-08-12 15:29:00 | Knockdown of HB-EGF in rat islets blocks beta-cell proliferation in response to glucose ex vivo and in vivo in transplanted glucose-infused rats. Findings identify a novel glucose/HB-EGF/EGFR axis implicated in beta-cell compensation to increased metabolic demand. | 31882563 |
| 2015-06-20 12:09:00 | Heterotrimeric G proteins directly regulate membrane-localized MMP14/MT1-MMP, resulting in HB-EGF release and EGFR transactivation. | 25759388 |
| 2014-11-08 12:18:00 | HB-EGF promotes hepatic stellate cell proliferation via activation of the EGFR and ErbB4 receptors | 24303948 |
| 2014-08-09 12:07:00 | FAK phosphorylation and FAK-mediated signal transduction play essential roles in HB-EGF-mediated intestinal epithelial cell migration and adhesion. | 24703506 |
| 2013-10-19 13:44:00 | Intraluminal administration of HB-EGF reduces the severity of intestinal congestion/repurfusion(C/R) injury in rats. | 23534509 |
| Type | IDs |
|---|---|
| Synonymous | Dtr, GFHB, Hb-egf, Hegfl |
| Gene |
UniProtKB-ID:
HBEGF_RAT
UniprotKB:
Q06175
UniParc:
UPI0000035E41
EMBL:
L05489
Ensembl:
ENSRNOG00000018646
KO:
rno:25433
|
| Nucleutide sequences |
EMBL-CDS:
AAA81780.1
Ensembl_TRS:
ENSRNOT00000025157
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000025157
RefSeq:
NP_037077.1
|
| Others |
UniRef100:
UniRef100_Q06175
UniRef90:
UniRef90_Q06175
UniRef50:
UniRef50_Q06175
UniGene:
Rn.10148
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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