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2541531 fft3

2541531

fft3

putative protein Fft3

protein-coding

Schizosaccharomyces pombe

基因描述

Type Description
Definition putative protein Fft3

研究结论

Date Results Publications
2020-07-04 12:10:00 Results found that Fft3 is important for DNA repair and is needed for single-strand annealing of an induced double-strand break. Furthermore, an inducible replication fork barrier system shows that Fft3 has two distinct roles at blocked DNA replication forks. First, Fft3 is needed for the resection of nascent strands, and second, it is required to restart the blocked forks independently of its ATPase activity. 31575705
2018-12-01 12:10:00 Data indicate Fun30(Fft3) as a chromatin remodeller, which localizes at transcribing regions to promote RNA polymerase II (RNAPII) transcription. 28218250
2018-11-10 12:00:00 These analyses of the regulation of nucleosome dynamics by Fun30(Fft3) during RNA polymerase II (RNAPII) -mediated transcription reveal an unprecedented role for a chromatin remodeler in nucleosome disassembly at transcribing regions. They offer a new conceptual framework that can describe, in mathematical terms, how nucleosome dynamics are controlled during RNAPII-mediated elongation. 28925811
2017-09-09 14:43:00 This work uncovers a conserved factor critical for epigenetic inheritance of heterochromatin and describes a mechanism in which Fft3 suppresses nucleosome turnover, preventing formation of structural barriers that impede replication at fragile regions in the genome. 28318821
2016-01-02 11:00:00 We propose that Fft3 has a global role in mediating association between specific chromatin domains and the nuclear envelope 25798942

名称对应

Type IDs
Synonymous snf2SR
Gene
UniProtKB-ID: FFT3_SCHPO
UniprotKB: O42861
UniParc: UPI000006B5BE
EMBL: AB027947, CU329670
EnsemblGenome: SPAC25A8.01c
KO: spo:SPAC25A8.01c
Nucleutide sequences
EMBL-CDS: CAA16951.1, BAA87251.1
Gene_ORFName: SPAC25A8.01c
EnsemblGenome_TRS: SPAC25A8.01c.1
Protein sequencees
EnsemblGenome_PRO: SPAC25A8.01c.1:pep
RefSeq: NP_593617.1
Others
UniRef100: UniRef100_O42861
UniRef90: UniRef90_O42861
UniRef50: UniRef50_O42861

全选

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研究热度

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