| Type | Description |
|---|---|
| Definition | DNA repair and recombination protein |
| Date | Results | Publications |
|---|---|---|
| 2020-04-18 11:35:00 | The unwinding of double-stranded DNA by Pif1 is dominated by highly processive and repetitive attempts of partial DNA opening. | 31744872 |
| 2019-07-13 10:59:00 | The nuclear isoform of Pfh1 (nPfh1) unwound RNA/DNA hybrids more efficiently than DNA/DNA. Pfh1 resolves RNA/DNA structures like R-loops in vivo. nPfh1 displaced proteins from DNA and possessed strand-annealing activity. The unwinding and protein displacement activities were dependent on the Pif1 signature motif. nPfh1-L430P and nPfh1-Delta21 still displayed binding to G-quadruplex DNA and strand-annealing. | 30053106 |
| 2017-06-24 11:39:00 | The nuclear isoform of Pfh1 (nPfh1) unwound both types of structure, and although the G4-stabilizing compound Phen-DC3 significantly enhanced their stability, nPfh1 still resolved them efficiently | 27185885 |
| 2017-05-20 11:52:00 | In budding and fission yeasts, Pif1 family helicases impact both telomerase-mediated and semi-conservative replication of telomeric DNA as well as recombination-mediated telomere lengthening. (Review) | 27233114 |
| 2017-05-13 13:33:00 | Pfh1 is an accessory DNA helicase that interacts with the replisome and promotes replication and suppresses DNA damage at hard-to-replicate sites. | 27611590 |
| Type | IDs |
|---|---|
| Synonymous | pif1 |
| Gene |
UniProtKB-ID:
PIF1_SCHPO
UniprotKB:
Q9UUA2
UniParc:
UPI0003994EA9,
UPI0000131AA0
EMBL:
AF074944,
CU329671
EnsemblGenome:
SPBC887.14c
KO:
spo:SPBC887.14c
|
| Nucleutide sequences |
EMBL-CDS:
CAA21899.1,
AAC26139.1
Gene_ORFName:
SPBC887.14c
EnsemblGenome_TRS:
SPBC887.14c.1
|
| Protein sequencees |
EnsemblGenome_PRO:
SPBC887.14c.1:pep
RefSeq:
NP_596488.1
|
| Others |
UniRef100:
UniRef100_Q9UUA2
UniRef90:
UniRef90_Q9UUA2
UniRef50:
UniRef50_Q9UUA2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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