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2540694 bqt4

2540694

bqt4

bouquet formation protein Bqt4

protein-coding

Schizosaccharomyces pombe

基因描述

Type Description
Definition bouquet formation protein Bqt4

研究结论

Date Results Publications
2020-05-23 12:43:00 our data demonstrate that Rap1-Bqt4-dependent telomere association to nuclear envelope preserves telomere integrity in post-mitotic cells, preventing telomeric transcription and recombination 31980821
2020-03-28 10:29:00 Data report the crystal structure of the N-terminal domain of Bqt4 which resembles the APSES-family DNA-binding domain and has a moderate double- stranded DNA-binding activity. Disruption of Bqt4-DNA interaction results in telomere detachment from the nuclear envelope (NE) suggesting that the DNA-binding activity of Bqt4 may function to prime the chromosome onto the NE and promote telomere- NE association. 30503780
2019-08-24 11:59:00 Phosphorylation of Bqt4-interacting proteins may act as a switch to regulate these interactions during cell cycles. Our studies provide structural insights into the identification and regulation of Bqt4-mediated interactions. 30462301
2018-09-29 12:05:00 Study shows that Lem2 is retained at the nuclear envelope through its interaction with Bqt4, as the loss of Bqt4 results in the exclusive accumulation of Lem2 to the spindle pole body. An N-terminal nucleoplasmic region of Lem2 bears affinity to both Bqt4 and the SPB in a competitive manner. 29292846

名称对应

Type IDs
Gene
UniProtKB-ID: BQT4_SCHPO
UniprotKB: O60158
UniParc: UPI000006A073
EMBL: AB027792, CU329671
EnsemblGenome: SPBC19C7.10
KO: spo:SPBC19C7.10
Nucleutide sequences
EMBL-CDS: CAB43057.1, BAA87096.1
Gene_ORFName: SPBC19C7.10
EnsemblGenome_TRS: SPBC19C7.10.1
Protein sequencees
EnsemblGenome_PRO: SPBC19C7.10.1:pep
RefSeq: NP_596166.1
Others
UniRef100: UniRef100_O60158
UniRef90: UniRef90_O60158
UniRef50: UniRef50_O60158

全选

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研究热度

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