| Type | Description |
|---|---|
| Definition | bromodomain and WD repeat domain containing 3 |
| Date | Results | Publications |
|---|---|---|
| 2017-12-02 11:01:00 | BCL7A, BRWD3, and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations. | 29166413 |
| 2014-12-20 12:39:00 | A nonsense mutation in BRWD3 in a family with X-linked intellectual disability associated with macrocephaly. | 24462886 |
| 2012-06-09 11:23:00 | potential serological biomarker of breast cancer | 22024541 |
| 2010-05-12 21:01:00 | Includes the identification of truncating mutations in this gene that segregated with mental retardation in the families tested. | 19377476 |
| 2010-01-21 00:00:00 | BRWD3 is therefore a new gene implicated in the etiology of XLMR associated with macrocephaly and may cause disease by altering intracellular signaling pathways affecting cellular proliferation. | 17668385 |
| Type | IDs |
|---|---|
| Synonymous | BRODL, MRX93 |
| Gene |
UniProtKB-ID:
BRWD3_HUMAN
UniprotKB:
Q6RI45
UniParc:
UPI0001AE6FE3,
UPI00004185B7,
UPI000045785B,
UPI0001E88EAC,
UPI0001E88EAB
EMBL:
AK095887,
AY497054,
AY497047,
AL669934,
AY497059,
AY497058,
AY497051,
AY497048,
AY497056,
AY497046,
AY497052,
AL512504,
AY497055,
AY497057,
BC111490,
AY497060,
AY497049,
AY497053,
AY497050,
AL590031
Ensembl:
ENSG00000165288
KO:
hsa:254065
|
| Nucleutide sequences |
EMBL-CDS:
AAS45479.1,
AAS45480.1,
BAC04641.1,
AAS45485.1,
AAS45481.1,
AAS45476.1,
AAS45478.1,
AAS45471.1,
AAS45475.1,
AAS45474.1,
AAS45483.1,
AAI11491.1,
AAS45472.1,
AAS45482.1,
AAS45473.1,
AAS45477.1,
AAS45484.1
Ensembl_TRS:
ENST00000373275
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000362372
RefSeq:
XP_016884874.1,
XP_016884873.1,
XP_005262170.1,
NP_694984.5
|
| Others |
UniRef100:
UniRef100_Q6RI45
UniRef90:
UniRef90_Q6RI45
UniRef50:
UniRef50_Q6RI45
UniGene:
Hs.147027,
Hs.613180
CCDS:
CCDS14447.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员