ETFBKMT - electron transfer flavoprotein subunit beta lysine methyltransferase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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254013 ETFBKMT

基因描述

Type	Description
Definition	electron transfer flavoprotein subunit beta lysine methyltransferase

研究结论

Date	Results	Publications
2018-12-01 11:33:00	These results further indicate that METTL20-mediated protein methylation is not essential in humans but more likely modulates energy production during fasting or under other metabolic conditions where beta-oxidation is up-regulated.	29352221
2015-04-11 10:22:00	Human METTL20 is a mitochondrial lysine methyltransferase that targets ETFbeta and modulates its activity.	25416781
2015-01-24 10:08:00	Tagged METTL20 expressed in HEK293T cells specifically associates with the ETF and promotes the trimethylation of ETFbeta lysine residues 199 and 202	25023281
2014-04-22 09:47:00	The METTL20 protein is here suggested to be a protein methyltransferase, as it is shown to belong to a family of 10 human methyltransferases, some of which are shown to have lysine specific protein methyltransferase activity.	22948820

名称对应

Type	IDs
Synonymous	C12orf72, ETFB-KMT, METTL20
Gene	UniProtKB-ID: ETKMT_HUMAN UniprotKB: Q8IXQ9 UniParc: UPI000007435A EMBL: BC039535, CH471116, AK290248, BC039107 Ensembl: ENSG00000139160 KO: hsa:254013
Nucleutide sequences	EMBL-CDS: EAW88548.1, AAH39535.1, EAW88545.1, AAH39107.1, EAW88547.1, BAF82937.1 Ensembl_TRS: ENST00000357721, ENST00000395763, ENST00000412352, ENST00000538463
Protein sequencees	Ensembl_PRO: ENSP00000396123, ENSP00000350353, ENSP00000379112, ENSP00000441421 RefSeq: XP_024304692.1, NP_001129335.1, XP_024304693.1, NP_776163.1, NP_001129336.1, XP_024304691.1
Others	UniRef100: UniRef100_Q8IXQ9 UniRef90: UniRef90_Q8IXQ9 UniRef50: UniRef50_Q8IXQ9 UniGene: Hs.740628 CCDS: CCDS8724.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
29987050	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Proc. Natl. Acad. Sci. U.S.A. Tengfei Xiao , Wei Li , Xiaoqing Wang , Han Xu , Jixin Yang , Qiu Wu , Ying Huang , Joseph Geradts , Peng Jiang , Teng Fei , David Chi , Chongzhi Zang , Qi Liao , Jonathan Rennhack , Eran Andrechek , Nanlin Li , Simone Detre , Mitchell Dowsett , Rinath M Jeselsohn , X Shirley Liu , Myles Brown	2018-07-31	-
29352221	Role of METTL20 in regulating Î²-oxidation and heat production in mice under fasting or ketogenic conditions. Sci Rep Tadahiro Shimazu , Tamio Furuse , Shabeesh Balan , Ikuko Yamada , Shuzo Okuno , Hiroko Iwanari , Takehiro Suzuki , Takao Hamakubo , Naoshi Dohmae , Takeo Yoshikawa , Shigeharu Wakana , Yoichi Shinkai	2018-01-19	-
29053956	Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. Mol Cell Peng Tan , Lian He , Jun Cui , Chen Qian , Xin Cao , Meng Lin , Qingyuan Zhu , Yinyin Li , Changsheng Xing , Xiao Yu , Helen Y Wang , Rong-Fu Wang	2017-10-19	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
26186194	The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell Edward L Huttlin , Lily Ting , Raphael J Bruckner , Fana Gebreab , Melanie P Gygi , John Szpyt , Stanley Tam , Gabriela Zarraga , Greg Colby , Kurt Baltier , Rui Dong , Virginia Guarani , Laura Pontano Vaites , Alban Ordureau , Ramin Rad , Brian K Erickson , Martin WÃ¼hr , Joel Chick , Bo Zhai , Deepak Kolippakkam , Julian Mintseris , Robert A Obar , Tim Harris , Spyros Artavanis-Tsakonas , Mathew E Sowa , Pietro De Camilli , Joao A Paulo , J Wade Harper , Steven P Gygi	2015-07-16	-
25416781	Human METTL20 is a mitochondrial lysine methyltransferase that targets the Î² subunit of electron transfer flavoprotein (ETFÎ²) and modulates its activity. J Biol Chem JÄdrzej MaÅecki , Angela Y Y Ho , Anders Moen , Helge-AndrÃ© Dahl , PÃ¥l Ã Falnes	2015-01-02	-
25023281	Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria. J. Biol. Chem. Virginie F Rhein , Joe Carroll , Jiuya He , Shujing Ding , Ian M Fearnley , John E Walker	2014-08-29	-
23349634	A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. PLoS Genet. Philippe Cloutier , Mathieu LavallÃ©e-Adam , Denis Faubert , Mathieu Blanchette , Benoit Coulombe	2013-01-01	PGK1, SEC53, NNT1, FUN12, CDC48, MPM1, HUWE1, LRPPRC, PDIA6, DNAJA2, TUBB3, TUBB4A, PPIH, PFDN6, CARM1, IPO7, CCT7, CCT4, CCT2, CCT6B, CCT8, HSPH1, TUBGCP2, RUVBL2, STIP1, EXOSC8, METTL23, HIST2H3C, CSTA, CTSB, METTL21A, DYNC1H1, EEF2, EEF2KMT, METTL21C, FOXK1, ALDOA, HSPA4L, KIN, CCT5, KDM1A, GANAB, EXOSC2, CASP14, HSPBP1, ETFBKMT, METTL21B, TIPRL, EIF3K, HEXB, ANXA6, DNAJA1, HSPA1A, HSPA1B, HSPA1L, HSPA2, HSPA4, HSPA5, HSPA7, HSPA8, HSPA9, HSP90AA1, HSP90AB1, HSPD1, IARS, IGBP1, TUBB8, TUBB2B, HSP90AB2P, LAMP2, LDHA, LDHB, MAT2A, MDH2, METTL1, EXOSC1, DNAJB11, PFDN1, PFDN2, PFDN4, PFDN5, POLR2H, PRMT6, FAM86C1, PPP6C, RNF126, CCDC88A, UGGT2, SAR1A, UGGT1, CCAR2, RARS, RPL3, S100A7, S100A9, TUBBP5, HNRNPCL3, FAM86B2, SNRPA1
22948820	Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nat Commun Stefan Kernstock , Erna Davydova , Magnus Jakobsson , Anders Moen , Solveig Pettersen , Gunhild M MÃ¦landsmo , Wolfgang Egge-Jacobsen , PÃ¥l Ã Falnes	2012-01-01	-
17207965	hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics Philippe Lamesch , Ning Li , Stuart Milstein , Changyu Fan , Tong Hao , Gabor Szabo , Zhenjun Hu , Kavitha Venkatesan , Graeme Bethel , Paul Martin , Jane Rogers , Stephanie Lawlor , Stuart McLaren , AmÃ©lie Dricot , Heather Borick , Michael E Cusick , Jean Vandenhaute , Ian Dunham , David E Hill , Marc Vidal	2007-03-01	GNPDA1, CTAGE4, BCL2L11, PIGK, TIMM23, NPIPA5, CST8, AP1M2, COX17, TIMM23B, SNX29P1, IL18BP, RWDD2B, TSSC4, UPK1A-AS1, ARPC5, ARPC3, TSPAN5, TSPAN3, TSPAN1, PPIF, CTDSP2, NAMPT, PDZK1IP1, DHRS9, RBM7, MPHOSPH6, DHRS2, MPZL2, GPA33, CALCOCO2, SPRY3, SPRY1, RAMP3, TRAIP, DNAJA2, IKZF1, CRISP3, SIRPB1, CNPY2, B3GNT3, WARS2, NPM3, CDO1, CACNG3, TUBB4B, CEPT1, PEMT, WFDC2, NSA2, EMG1, TIMM17A, PPIE, HAX1, CIB2, DCTN2, RPP38, SLC35A1, IFI44, CXCL13, SIVA1, MRPL28, CENPA, MAB21L2, RAD51AP1, MTX2, CGRRF1, DCTN6, B3GNT2, CLDN16, PNMA2, KLRA1P, SRSF10, ARPP21, STARD10, CGA, EDDM3A, CFHR3, GPR83, RAB10, CPSF4, RUNDC3A, COPS8, C11orf58, CCDC85B, GLIPR1, KLK11, SNRNP27, LIAS, LILRA2, SNRNP35, CYB561D2, ESM1, WDR5, BTN2A1, HHLA3, BVES, KLK8, MRPL3

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