| Type | Description |
|---|---|
| Definition | telomere-binding protein Rap1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 12:43:00 | our data demonstrate that Rap1-Bqt4-dependent telomere association to nuclear envelope preserves telomere integrity in post-mitotic cells, preventing telomeric transcription and recombination | 31980821 |
| 2020-02-15 13:09:00 | We demonstrate that deletion of Rap1 is protective in this context, preventing the growth crisis that is otherwise triggered by degradation of telomeric R-loops in survivors with linear chromosomes. These findings suggest that upregulation of telomere-engaged TERRA, or altered recruitment of shelterin components, can support telomerase-independent telomere maintenance. | 31405990 |
| 2020-01-11 11:35:00 | Fission yeast cells lacking shelterin components Taz1 or Rap1 showed higher gross chromosomal rearrangements (GCRs) rates compared to wild-type, accumulating large chromosome deletions. Study results highlight unappreciated functions of the shelterin components Taz1 and Rap1 in maintaining genome stability, specifically by preventing non-telomeric GCRs. | 31454352 |
| 2020-01-11 10:46:00 | Rap1 is phosphorylated by CK2 at multiple sites, which promotes interactions with Bqt4 and Poz1. Phosphorylation at Ser496 was found to be crucial for both Rap1-Bqt4 and Rap1-Poz1 interactions.These mechanisms mediate proper telomere tethering to the NE and the formation of the silenced chromatin structure at chromosome ends. | 31131414 |
| 2019-07-13 11:34:00 | Telosome formation depends on the conserved telomeric proteins Taz1 and Rap1, and RNA. Rap1Delta telomeres lack detectable telosomes. Taz1 and Rap1 act together in organizing the telosome. | 29992245 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
RAP1_SCHPO
UniprotKB:
Q96TL7
UniParc:
UPI0000133112
EMBL:
AY034032,
AB061738,
AB027870,
AB027963,
CU329671
EnsemblGenome:
SPBC1778.02
KO:
spo:SPBC1778.02
|
| Nucleutide sequences |
EMBL-CDS:
CAC39280.1,
BAB70735.1,
BAA87174.1,
AAK57740.1,
BAA87267.1
Gene_ORFName:
SPBC1778.02
EnsemblGenome_TRS:
SPBC1778.02.1
|
| Protein sequencees |
EnsemblGenome_PRO:
SPBC1778.02.1:pep
RefSeq:
NP_596285.1
|
| Others |
UniRef100:
UniRef100_Q96TL7
UniRef90:
UniRef90_Q96TL7
UniRef50:
UniRef50_Q96TL7
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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