| Type | Description |
|---|---|
| Definition | microtubule polymerase alp14 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-12 10:37:00 | In the fission yeast Schizosaccharomyces pombe, the XMAP215 ortholog Alp14 is critical for efficient MT nucleation in vivo. In multiple assays, loss of Alp14 function led to reduced nucleation rate and numbers of interphase MT bundles. Conversely, activation of Alp14 led to increased nucleation frequency. | 29779879 |
| 2016-12-17 11:48:00 | The ability of Alp7/14 to accelerate and bias GTP-tubulin exchange at microtubule plus ends allows it to generate long-lived, fast-growing microtubules at very low cellular free tubulin concentrations. | 26864000 |
| 2015-02-28 12:09:00 | CDK phosphorylates the Alp7-Alp14 complex to localize it to the nucleus. | 24790093 |
| 2013-11-02 11:38:00 | An Ndc80 loop plays sequential roles in spindle-kinetochore attachment by connecting the Ndc80 complex to Dis1/TOG and Alp7/TACC-Alp14/TOG. | 23427262 |
| 2013-04-06 12:25:00 | studies suggest that Alp14 regulates the polymerization state of tubulin by cycling between a tubulin dimer-bound cytoplasmic state and a MT polymerase state that promotes rapid MT assembly. | 22696680 |
| Type | IDs |
|---|---|
| Synonymous | mtc1 |
| Gene |
UniProtKB-ID:
ALP14_SCHPO
UniprotKB:
O94534
UniParc:
UPI0000125794
EMBL:
AB032409,
CU329672
EnsemblGenome:
SPCC895.07
KO:
spo:SPCC895.07
|
| Nucleutide sequences |
EMBL-CDS:
BAA84527.1,
CAA22843.1
Gene_ORFName:
SPCC895.07
EnsemblGenome_TRS:
SPCC895.07.1
|
| Protein sequencees |
EnsemblGenome_PRO:
SPCC895.07.1:pep
RefSeq:
NP_588048.1
|
| Others |
UniRef100:
UniRef100_O94534
UniRef90:
UniRef90_O94534
UniRef50:
UniRef50_O94534
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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