| Type | Description |
|---|---|
| Definition | switch-activating protein Sap1 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-19 12:12:00 | Crystal structure results identified a dimerization interface between Sap1 monomers that predicted to be engaged in the direct repeat binding mode. Interestingly, mutations in Sap1 which rescue the CENP-B deletion phenotype lie at or near this dimerization interface. | 30026545 |
| 2017-04-29 10:57:00 | Sap1 is a replication-initiation factor that directly participates in the assembly of the pre-RC. DNA-replication origins in fission yeast are defined by possessing two essential elements with one bound by ORC and the other by Sap1. | 28223353 |
| 2015-10-24 11:30:00 | This study shows that insertion of the fission yeast LTR retrotransposon Tf1 is guided by the DNA binding protein Sap1 and that the efficiency and location of the targeting depend on the activity of Sap1 as a replication fork barrier. | 26404838 |
| 2010-01-21 00:00:00 | Results reveal that Sap1-DNA affinity alone is insufficient to account for fork arrest and suggest that Sap1 binding-induced structural changes may result in formation of a competent fork-blocking complex. | 16940176 |
| 2010-01-21 00:00:00 | Sap1p binds the rDNA fork barrier Ter1 to cause polar replication fork arrest at this site but not at SAS1. | 16195226 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SAP1_SCHPO
UniprotKB:
P40847
UniParc:
UPI0000135542
EMBL:
X77578,
CU329672
EnsemblGenome:
SPCC1672.02c
KO:
spo:SPCC1672.02c
|
| Nucleutide sequences |
EMBL-CDS:
CAA54684.1,
CAA20440.1
Gene_ORFName:
SPCC1672.02c
EnsemblGenome_TRS:
SPCC1672.02c.1
|
| Protein sequencees |
EnsemblGenome_PRO:
SPCC1672.02c.1:pep
RefSeq:
NP_587873.1
|
| Others |
UniRef100:
UniRef100_P40847
UniRef90:
UniRef90_P40847
UniRef50:
UniRef50_P40847
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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