| Type | Description |
|---|---|
| Definition | Smc5-6 complex SMC subunit Smc6 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-07 10:15:00 | Authors show that the chromatin association and SUMO ligase activity of Smc5-Smc6 require the Nse5-Nse6 heterodimer, explaining how this nonessential cofactor critically supports the DNA repair roles of Smc5-Smc6. | 30348841 |
| 2019-07-20 11:04:00 | I summarize new research that is beginning to tease out the molecular details of Smc5/6 structure and function, knowledge that will illuminate the nuclear activities of Smc5/6 in the stability and dynamics of eukaryotic genomes | 30476445 |
| 2018-11-24 12:20:00 | Study shows that the Smc5/6-hinge complex binds preferentially to ssDNA and that this interaction is affected by both 'latch' and 'hub' mutations, suggesting a key role for these unique features in controlling DNA association by the Smc5/6 complex. | 28134253 |
| 2017-11-18 12:50:00 | Results provide evidence that Brc1 provides scaffolding functions linking gammaH2A, Rhp18, and Smc5/6 complex at damaged replication forks. | 28784724 |
| 2016-12-17 10:39:00 | The function of the SMC5/6 complex and its mammalian homologs in the cell cycle has not been clarified yet. | 26743946 |
| Type | IDs |
|---|---|
| Synonymous | rad18 |
| Gene |
UniProtKB-ID:
SMC6_SCHPO
UniprotKB:
P53692
UniParc:
UPI0000133014
EMBL:
X80929,
CU329672
EnsemblGenome:
SPCC5E4.06
KO:
spo:SPCC5E4.06
|
| Nucleutide sequences |
EMBL-CDS:
CAA56900.1,
CAA21961.1
Gene_ORFName:
SPCC5E4.06
EnsemblGenome_TRS:
SPCC5E4.06.1
|
| Protein sequencees |
EnsemblGenome_PRO:
SPCC5E4.06.1:pep
RefSeq:
NP_587906.1
|
| Others |
UniRef100:
UniRef100_P53692
UniRef90:
UniRef90_P53692
UniRef50:
UniRef50_P53692
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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