| Type | Description |
|---|---|
| Definition | FYN binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 12:09:00 | Findings reveal that ADAP acts upstream of SLP-76 to convert labile, Ca(2+)-competent microclusters into stable adhesive junctions with enhanced signaling potential. | 30305305 |
| 2018-06-08 10:45:00 | results of this study indicate that a novel T cell adaptor protein, activation-dependent, raft-recruited ADAP-like phosphoprotein (ARAP), plays a unique role in T cells as a part of both the proximal activation signaling and inside-out signaling pathways that result in integrin activation and T cell adhesion | 27335501 |
| 2017-12-30 10:45:00 | Ubc9 is an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL and for activation of the small GTPase Rac1 in T cell adhesion. | 29127148 |
| 2017-10-07 10:12:00 | Current knowledge of the functions of the adapter protein ADAP in T cell signaling with a focus on the role of individual phosphotyrosine (pY) motifs for SH2 domain mediated interactions is presented. | 27258783 |
| 2016-08-13 11:57:00 | A distinct set of proteins interaction partners required for chemokine-directed T cell migration is attracted by phosphotyrosine 571 of ADAP, including ZAP70. | 26246585 |
| Type | IDs |
|---|---|
| Synonymous | ADAP, FYB, PRO0823, SLAP-130, SLAP130, THC3 |
| Gene |
UniProtKB-ID:
FYB1_HUMAN
UniprotKB:
O15117
UniParc:
UPI00017A75FB,
UPI000020C9D6,
UPI000020C9D5
EMBL:
AC010633,
CH471119,
BC143645,
AK297077,
AC008964,
AK290403,
U93049,
AF001862,
AC025471,
AF198052,
BC117449
Ensembl:
ENSG00000082074
KO:
hsa:2533
|
| Nucleutide sequences |
EMBL-CDS:
AAI43646.1,
AAI17450.1,
BAG59594.1,
EAW55984.1,
AAB62226.1,
BAF83092.1,
AAF62400.1,
AAC51300.1
Ensembl_TRS:
ENST00000351578,
ENST00000646045,
ENST00000512982,
ENST00000515010
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000493623,
ENSP00000425845,
ENSP00000426346,
ENSP00000316460
RefSeq:
XP_011512313.1,
XP_006714529.1,
XP_006714527.1,
NP_955367.1,
XP_011512311.1,
NP_001336262.1,
XP_011512312.1,
NP_001456.3,
NP_061064.2,
XP_011512315.1,
NP_001230022.1,
XP_011512310.1,
XP_011512314.1
|
| Others |
UniRef100:
UniRef100_O15117
UniRef90:
UniRef90_O15117
UniRef50:
UniRef50_O15117
UniGene:
Hs.370503,
Hs.691768
CCDS:
CCDS47200.1,
CCDS54848.1,
CCDS58945.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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