| Type | Description |
|---|---|
| Definition | Rap guanine nucleotide exchange factor 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-15 19:06:00 | Exchange protein directly activated by cAMP 2 is required for corticotropin-releasing hormone-mediated spine loss. | 31199033 |
| 2018-12-29 10:40:00 | Epac1/Epac2 and CaM can play a key role in arrhythmogenesis development under conditions of alcoholic cardiomyopathy. | 30225708 |
| 2017-08-12 12:05:00 | Data suggest that Rap2A is the obligate effector for Epac2 in mediating growth arrest and reversal of neurite extension through activation of MAP kinase signaling via protein phosphorylation/farnesylation in neuroendocrine cells. (Rap2A = RAS oncogene family member Rap2A; Epac2 = guanine nucleotide exchange factor Epac2) | 28546426 |
| 2017-06-24 11:42:00 | Rap guanine nucleotide exchange factors Epac1 and Epac2 induces the phosphorylation of extracellular signal-regulated kinases ERK1/2 in pituitary tumor GH3 cells. | 28216156 |
| 2017-02-18 10:24:00 | Data suggest activation of EPAC1/2 (exchange proteins activated by cAMP) and Rap1 (RAS-related GTP-binding protein 1) in hepatic stellate cells down-regulates proliferation and synthesis of a-smooth muscle actin/collagen I/collagen II in an in vitro model of alcoholic cirrhosis (AC); in AC, expression of EPAC1 is down-regulated but expression of EPAC2 is up-regulated; EPAC1 activation increases GTP-bound (activated) Rap1. | 26854595 |
| Type | IDs |
|---|---|
| Synonymous | CAMP-GEFII, CAMPS, Cgef2, Epac2 |
| Gene |
UniProtKB-ID:
D3KR63_RAT
UniprotKB:
D3KR63
UniParc:
UPI000050672E
EMBL:
AB031229
KO:
rno:252857
|
| Nucleutide sequences |
EMBL-CDS:
BAI77419.1
|
| Protein sequencees |
RefSeq:
XP_017447653.1,
NP_001094112.1,
XP_001060956.2
|
| Others |
UniRef100:
UniRef100_D3KR63
UniRef90:
UniRef90_Q8WZA2
UniRef50:
UniRef50_Q8WZA2
UniGene:
Rn.42890
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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