| Type | Description |
|---|---|
| Definition | MYCN proto-oncogene, bHLH transcription factor |
| Date | Results | Publications |
|---|---|---|
| 2017-11-25 15:21:00 | In MYCN transgenic fish, Gab2 overexpression activated the Shp2-Ras-Erk pathway, enhanced neuroblastoma induction, and increased tumor penetrance. | 28329685 |
| 2017-10-21 11:20:00 | The authors demonstrate in zebrafish that nf1 loss leads to aberrant activation of RAS signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma in nf1-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 mutant embryos. | 27130733 |
| 2010-01-21 00:00:00 | At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches. | 15661639 |
| Type | IDs |
|---|---|
| Synonymous | N-myc, fb57a02, nmyc1, wu:fb57a02, zgc:85706 |
| Gene |
UniProtKB-ID:
Q5GFD4_DANRE
UniprotKB:
Q5GFD4
UniParc:
UPI000043780F
EMBL:
AY583215
KO:
dre:252851
|
| Nucleutide sequences |
EMBL-CDS:
AAT90361.1
|
| Protein sequencees |
RefSeq:
NP_997779.2
|
| Others |
UniRef100:
UniRef100_Q9PSJ0
UniRef90:
UniRef90_Q9PSJ0
UniRef50:
UniRef50_P24793
UniGene:
Dr.75499
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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