| Type | Description |
|---|---|
| Definition | dual specificity tyrosine phosphorylation regulated kinase 1A |
| Date | Results | Publications |
|---|---|---|
| 2018-09-01 10:27:00 | Dyrk1A involved in the regulation of alternative splicing of tau exon 10 in vivo. Overexpression of Dyrk1A in neonatal Ts65Dn mouse brains suppressed tau exon 10 inclusion, leading to an increase of 3R-tau/4R-tau ratio. Inhibition of Dyrk1A promotes endogenous tau exon 10 inclusion in cultured cells and in neonatal rat brain. | 28377597 |
| 2017-02-18 10:59:00 | Identify Dyrk1a as a novel negative regulator of D-cyclin-mediated Rb1/E2f-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy. | 27056896 |
| 2016-06-04 11:10:00 | Enhanced activation of Dyrk1A-ASF-CaMKIIdelta signaling pathway may underlie the mechanisms of HF after MI, and Dyrk1A inhibition may contribute to inactivation of this pathway and thereby retard the progression of MI-induced HF. | 26067684 |
| 2014-02-08 11:06:00 | calcineurin/NFAT pathway mediates the upregulation of PAI-1 by NGF | 23825664 |
| 2013-10-26 12:46:00 | A model of DYRK autoactivation has been proposed in which tyrosine autophosphorylation in the activation loop stabilizes a conformation of the catalytic domain with enhanced serine/threonine kinase activity without disabling tyrosine phosphorylation. | 23809146 |
| Type | IDs |
|---|---|
| Synonymous | Dyrk, PSK47 |
| Gene |
UniProtKB-ID:
DYR1A_RAT
UniprotKB:
Q63470
UniParc:
UPI000002A87E,
UPI0000129A32
EMBL:
X79769
Ensembl:
ENSRNOG00000001662
KO:
rno:25255
|
| Nucleutide sequences |
EMBL-CDS:
CAA56164.1
Ensembl_TRS:
ENSRNOT00000050342
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000042446
RefSeq:
XP_008766785.1,
NP_036923.1,
XP_008766786.1,
XP_006248093.1,
XP_008766787.1
|
| Others |
UniRef100:
UniRef100_Q63470
UniRef90:
UniRef90_Q13627
UniRef50:
UniRef50_Q13627
UniGene:
Rn.9354
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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