| Type | Description |
|---|---|
| Definition | spleen associated tyrosine kinase |
| Date | Results | Publications |
|---|---|---|
| 2019-08-24 10:05:00 | It was demonstrated in the present study that Syk was markedly activated in the development of Diabetic cardiomyopathy, subsequently promoting NLRP3 inflammasome activation through the phosphorylation of JNK, leading to the cleavage of pro-caspase-1 and maturation of IL-1beta, and finally contributing to diabetic cardiac dysfunction. | 30942391 |
| 2018-12-01 10:04:00 | mast cells contribute to Mincle-mediated immunity through Syk activation triggered by association with the FcepsilonRIbetagamma complex. | 28393919 |
| 2018-10-20 12:21:00 | present results determined that high glucoseinduced activation of the NLRP3 inflammasome is mediated by Syk/JNK activation, which subsequently increased the protein expression level of IL1beta and mature IL1beta. The present study identified that the Syk/JNK/NLRP3 signaling pathway may serve a vital role in the pathogenesis ofdiabetic nephropathy. | 29901140 |
| 2018-10-20 10:20:00 | Cryptotanshinone inhibits IgEmediated degranulation through inhibition of spleen tyrosine kinase and tyrosineprotein kinase phosphorylation in mast cells. | 29845271 |
| 2015-10-24 10:33:00 | Brain Syk expression is upregulated after subarachnoid hemorrhage. | 26138128 |
| Type | IDs |
|---|---|
| Synonymous | p72syk |
| Gene |
UniProtKB-ID:
KSYK_RAT
UniprotKB:
Q64725
UniParc:
UPI000002AD06,
UPI000012E0DF
EMBL:
U21684,
U21683
KO:
rno:25155
|
| Nucleutide sequences |
EMBL-CDS:
AAA75166.1,
AAA75167.1
|
| Protein sequencees |
RefSeq:
NP_036890.2
|
| Others |
UniRef100:
UniRef100_Q64725
UniRef90:
UniRef90_P48025
UniRef50:
UniRef50_P48025
UniGene:
Rn.87407
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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