| Type | Description |
|---|---|
| Definition | tryptophan hydroxylase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 10:16:00 | tryptophan hydroxylase-1 (TPH1), an enzyme that catalyzes the reaction of Trp to serotonin, was significantly increased in liver and spleen of AT-2 engrafted rats. Further histochemical analysis revealed that the induction of TPH1 in the liver could be attributed to infiltration of mast cells. | 31997472 |
| 2020-03-14 12:41:00 | The testes of control animals express the Tph1, Aanat, and Asmt and Per2 genes with 24-h rhythms in mRNA, reaching the maximal values during the dark phase. | 31124080 |
| 2016-03-12 11:04:00 | Ursolic acid derivatives targeted to tryptophan hydroxylase 1 prevented bone loss by suppressing serotonin biosynthesis without estrogenic side-effects in ovariectomized rats. | 25930119 |
| 2014-05-17 11:21:00 | there exists possible interrelation between tyrosine hydroxylase and TPH gene expression and epigenetic histone acetylation in chronic unpredictable stress-induced depressive rats, which at least partly contributes to the etiology of depression. | 24495952 |
| 2013-02-09 11:11:00 | An increased expression of TPH1 in the dorsal raphe nucleus may be the primary mechanism to explain the chronic increase in the brain synthesis of 5-HT in these in utero malnourished rats. | 22819790 |
| Type | IDs |
|---|---|
| Synonymous | Tph |
| Gene |
UniProtKB-ID:
TPH1_RAT
UniprotKB:
P09810
UniParc:
UPI00001372B7
EMBL:
X53501,
M28000
Ensembl:
ENSRNOG00000011672
KO:
rno:24848
|
| Nucleutide sequences |
EMBL-CDS:
AAA42262.1,
CAA37579.1
Ensembl_TRS:
ENSRNOT00000056109
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000052959
RefSeq:
NP_001094104.1,
XP_006229281.1,
XP_006229280.1
|
| Others |
UniRef100:
UniRef100_P09810
UniRef90:
UniRef90_P17752
UniRef50:
UniRef50_P17752
UniGene:
Rn.94788
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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