| Type | Description |
|---|---|
| Definition | sodium voltage-gated channel alpha subunit 2 |
| Date | Results | Publications |
|---|---|---|
| 2018-05-26 11:16:00 | The Nav1.2 are highly expressed in axon terminals in central hilus compared to stratum radiatum and in dendrites and spines in stratum radiatum compared to central hilus . | 28758202 |
| 2018-01-13 12:51:00 | Knockdown of Nav1.2 channels in pre-oligodendrocyte alters their morphology, reduces axon-oligodendrocyte interactions and impairs myelination. | 28916793 |
| 2017-10-28 12:56:00 | Here, the authors show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule neurons (CGN) and that SUMOylation of NaV1.2 channels increases sodium current. | 28029095 |
| 2017-06-24 10:40:00 | The polarity of (Ca(2+))2-CaMC relative to the IQ motif of NaV1.2 was opposite to that seen in apo CaMC-Nav1.2IQp (2KXW), revealing that CaMC recognizes nested, anti-parallel sites in Nav1.2IQp. (CaMC is C-domain residues of CaM, calmodulin). | 28343066 |
| 2016-03-26 10:38:00 | miR-9 suppressed the trafficking of Nav1.1/Nav1.2 from cytoplasm to cell membrane. miR-9 overexpression inhibited Navbeta2 expression by targeting its coding sequence domain. | 26259688 |
| Type | IDs |
|---|---|
| Synonymous | NachII, Nav1.2, RII/RIIA, RNSCPIIR, SCN, Scn2a1, Scn2a2, ScpII |
| Gene |
UniProtKB-ID:
SCN2A_RAT
UniprotKB:
P04775
UniParc:
UPI00001279CA
EMBL:
X03639
KO:
rno:24766
|
| Nucleutide sequences |
EMBL-CDS:
CAA27287.1
|
| Protein sequencees |
RefSeq:
NP_036779.2
|
| Others |
UniRef100:
UniRef100_P04775
UniRef90:
UniRef90_P04775
UniRef50:
UniRef50_P04775
UniGene:
Rn.89192
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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