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246728 Oas2

246728

Oas2

2'-5' oligoadenylate synthetase 2

protein-coding

Mus musculus

基因描述

Type Description
Definition 2'-5' oligoadenylate synthetase 2

研究结论

Date Results Publications
2017-11-18 10:56:00 A non-synonymous mutation in Oas2 (I405N) in the viral sensor Oas2 was found and the mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammary glands, characterized by greatly reduced milk protein synthesis coupled with epithelial cell death, inhibition of proliferation and a robust interferon response. The mutation activates the OAS2 pathway. 29117179

名称对应

Type IDs
Synonymous Oasl11
Gene
UniProtKB-ID: OAS2_MOUSE
UniprotKB: E9Q9A9
UniParc: UPI0000026005, UPI0000194C62
EMBL: AB067535, AF418010, CH466529, AC115937
Ensembl: ENSMUSG00000032690
KO: mmu:246728
Nucleutide sequences
EMBL-CDS: EDL19753.1, AAM54499.1, BAB84135.1
Ensembl_TRS: ENSMUST00000081491, ENSMUST00000053909
Protein sequencees
Ensembl_PRO: ENSMUSP00000080209, ENSMUSP00000060082
RefSeq: NP_001334377.1, NP_660262.2, XP_036021033.1
Others
UniRef100: UniRef100_E9Q9A9
UniRef90: UniRef90_E9Q9A9
UniRef50: UniRef50_P29728
UniGene: Mm.260926
CCDS: CCDS19625.2, CCDS84949.1

全选

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