| Type | Description |
|---|---|
| Definition | Transmembrane protein 18 |
| Date | Results | Publications |
|---|---|---|
| 2017-06-10 13:00:00 | Our results suggest that TMEM18 affects substrate levels through insulin and glucagon signaling, and its downregulation induces a metabolic state resembling type 2 diabetes. This work is the first to experimentally describe the metabolic consequences of TMEM18 knockdown, and further supports its association with obesity. | 27029472 |
| Type | IDs |
|---|---|
| Synonymous | CG30051, Dmel\CG30051, anon-AE003822.1 |
| Gene |
UniProtKB-ID:
A1Z903_DROME
UniprotKB:
A1Z903
UniParc:
UPI00004C4F72
EMBL:
KX531367,
AE013599
EnsemblGenome:
FBgn0050051
KO:
dme:Dmel_CG30051
|
| Nucleutide sequences |
EMBL-CDS:
AAM68685.3,
ANY27177.1
Gene_ORFName:
CG30051,
Dmel_CG30051
EnsemblGenome_TRS:
FBtr0114521
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0113013
RefSeq:
NP_725169.3
|
| Others |
UniRef100:
UniRef100_A1Z903
UniRef90:
UniRef90_A1Z903
UniRef50:
UniRef50_A1Z903
UniGene:
Dm.23751
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 27172210 |
mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. G3 (Bethesda) Gildas Lepennetier , Francesco Catania |
2016-06-01 | - |
| 27029472 |
The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling. J. Endocrinol. Lyle Wiemerslage , Priya A Gohel , Giulia Maestri , Torfi G Hilmarsson , Michel Mickael , Robert Fredriksson , Michael J Williams , Helgi B Schiöth |
2016-06-01 | - |
| 26833246 |
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nat Commun Yingchang Lu , Felix R Day , Stefan Gustafsson , Martin L Buchkovich , Jianbo Na , Veronique Bataille , Diana L Cousminer , Zari Dastani , Alexander W Drong , Tõnu Esko , David M Evans , Mario Falchi , Mary F Feitosa , Teresa Ferreira , à sa K Hedman , Robin Haring , Pirro G Hysi , Mark M Iles , Anne E Justice , Stavroula Kanoni , Vasiliki Lagou , Rui Li , Xin Li , Adam Locke , Chen Lu , Reedik Mägi , John R B Perry , Tune H Pers , Qibin Qi , Marianna Sanna , Ellen M Schmidt , William R Scott , Dmitry Shungin , Alexander Teumer , Anna A E Vinkhuyzen , Ryan W Walker , Harm-Jan Westra , Mingfeng Zhang , Weihua Zhang , Jing Hua Zhao , Zhihong Zhu , Uzma Afzal , Tarunveer Singh Ahluwalia , Stephan J L Bakker , Claire Bellis , Amélie Bonnefond , Katja Borodulin , Aron S Buchman , Tommy Cederholm , Audrey C Choh , Hyung Jin Choi , Joanne E Curran , Lisette C P G M de Groot , Philip L De Jager , Rosalie A M Dhonukshe-Rutten , Anke W Enneman , Elodie Eury , Daniel S Evans , Tom Forsen , Nele Friedrich , Frédéric Fumeron , Melissa E Garcia , Simone Gärtner , Bok-Ghee Han , Aki S Havulinna , Caroline Hayward , Dena Hernandez , Hans Hillege , Till Ittermann , Jack W Kent , Ivana Kolcic , Tiina Laatikainen , Jari Lahti , Irene Mateo Leach , Christine G Lee , Jong-Young Lee , Tian Liu , Youfang Liu , Stéphane Lobbens , Marie Loh , Leo-Pekka Lyytikäinen , Carolina Medina-Gomez , Karl Michaëlsson , Mike A Nalls , Carrie M Nielson , Laticia Oozageer , Laura Pascoe , Lavinia Paternoster , Ozren PolaÅ¡ek , Samuli Ripatti , Mark A Sarzynski , Chan Soo Shin , Nina Smolej NaranÄiÄ , Dominik Spira , Priya Srikanth , Elisabeth Steinhagen-Thiessen , Yun Ju Sung , Karin M A Swart , Leena Taittonen , Toshiko Tanaka , Emmi Tikkanen , Nathalie van der Velde , Natasja M van Schoor , Niek Verweij , Alan F Wright , Lei Yu , Joseph M Zmuda , Niina Eklund , Terrence Forrester , Niels Grarup , Anne U Jackson , Kati Kristiansson , Teemu Kuulasmaa , Johanna Kuusisto , Peter Lichtner , Jian'an Luan , Anubha Mahajan , Satu Männistö , Cameron D Palmer , Janina S Ried , Robert A Scott , Alena Stancáková , Peter J Wagner , Ayse Demirkan , Angela Döring , Vilmundur Gudnason , Douglas P Kiel , Brigitte Kühnel , Massimo Mangino , Barbara Mcknight , Cristina Menni , Jeffrey R O'Connell , Ben A Oostra , Alan R Shuldiner , Kijoung Song , Liesbeth Vandenput , Cornelia M van Duijn , Peter Vollenweider , Charles C White , Michael Boehnke , Yvonne Boettcher , Richard S Cooper , Nita G Forouhi , Christian Gieger , Harald Grallert , Aroon Hingorani , Torben Jørgensen , Pekka Jousilahti , Mika Kivimaki , Meena Kumari , Markku Laakso , Claudia Langenberg , Allan Linneberg , Amy Luke , Colin A Mckenzie , Aarno Palotie , Oluf Pedersen , Annette Peters , Konstantin Strauch , Bamidele O Tayo , Nicholas J Wareham , David A Bennett , Lars Bertram , John Blangero , Matthias Blüher , Claude Bouchard , Harry Campbell , Nam H Cho , Steven R Cummings , Stefan A Czerwinski , Ilja Demuth , Rahel Eckardt , Johan G Eriksson , Luigi Ferrucci , Oscar H Franco , Philippe Froguel , Ron T Gansevoort , Torben Hansen , Tamara B Harris , Nicholas Hastie , Markku Heliövaara , Albert Hofman , Joanne M Jordan , Antti Jula , Mika Kähönen , Eero Kajantie , Paul B Knekt , Seppo Koskinen , Peter Kovacs , Terho Lehtimäki , Lars Lind , Yongmei Liu , Eric S Orwoll , Clive Osmond , Markus Perola , Louis Pérusse , Olli T Raitakari , Tuomo Rankinen , D C Rao , Treva K Rice , Fernando Rivadeneira , Igor Rudan , Veikko Salomaa , Thorkild I A Sørensen , Michael Stumvoll , Anke Tönjes , Bradford Towne , Gregory J Tranah , Angelo Tremblay , André G Uitterlinden , Pim van der Harst , Erkki Vartiainen , Jorma S Viikari , Veronique Vitart , Marie-Claude Vohl , Henry Völzke , Mark Walker , Henri Wallaschofski , Sarah Wild , James F Wilson , Loïc Yengo , D Timothy Bishop , Ingrid B Borecki , John C Chambers , L Adrienne Cupples , Abbas Dehghan , Panos Deloukas , Ghazaleh Fatemifar , Caroline Fox , Terrence S Furey , Lude Franke , Jiali Han , David J Hunter , Juha Karjalainen , Fredrik Karpe , Robert C Kaplan , Jaspal S Kooner , Mark I McCarthy , Joanne M Murabito , Andrew P Morris , Julia A N Bishop , Kari E North , Claes Ohlsson , Ken K Ong , Inga Prokopenko , J Brent Richards , Eric E Schadt , Tim D Spector , Elisabeth Widén , Cristen J Willer , Jian Yang , Erik Ingelsson , Karen L Mohlke , Joel N Hirschhorn , John Andrew Pospisilik , M Carola Zillikens , Cecilia Lindgren , Tuomas Oskari Kilpeläinen , Ruth J F Loos |
2016-02-01 | - |
| 26173873 |
Dev. Genes Evol. Albert J Erives |
2015-09-01 | - |
| 26109356 |
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders. G3 (Bethesda) Madeline A Crosby , L Sian Gramates , Gilberto Dos Santos , Beverley B Matthews , Susan E St Pierre , Pinglei Zhou , Andrew J Schroeder , Kathleen Falls , David B Emmert , Susan M Russo , William M Gelbart , FlyBase Consortium |
2015-08-01 | - |
| 26109357 |
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. G3 (Bethesda) Beverley B Matthews , Gilberto Dos Santos , Madeline A Crosby , David B Emmert , Susan E St Pierre , L Sian Gramates , Pinglei Zhou , Andrew J Schroeder , Kathleen Falls , Victor Strelets , Susan M Russo , William M Gelbart , FlyBase Consortium |
2015-06-24 | - |
| 25589440 |
The Release 6 reference sequence of the Drosophila melanogaster genome. Genome Res. Roger A Hoskins , Joseph W Carlson , Kenneth H Wan , Soo Park , Ivonne Mendez , Samuel E Galle , Benjamin W Booth , Barret D Pfeiffer , Reed A George , Robert Svirskas , Martin Krzywinski , Jacqueline Schein , Maria Carmela Accardo , Elisabetta Damia , Giovanni Messina , MarÃa Méndez-Lago , Beatriz de Pablos , Olga V Demakova , Evgeniya N Andreyeva , Lidiya V Boldyreva , Marco Marra , A Bernardo Carvalho , Patrizio Dimitri , Alfredo Villasante , Igor F Zhimulev , Gerald M Rubin , Gary H Karpen , Susan E Celniker |
2015-03-01 |
ARY,
CG45781,
Pzl,
Myo81F,
kl-3,
kl-5,
PRY,
WDY,
CCY,
Pp1-Y2,
ORY,
Ppr-Y,
kl-2,
Pp1-Y1,
FDY
|
| 25312911 |
Phylostratigraphic bias creates spurious patterns of genome evolution. Mol. Biol. Evol. Bryan A Moyers , Jianzhi Zhang |
2015-01-01 | - |
| 24508822 |
From fat fruit fly to human obesity. Physiol. Behav. Wanli W Smith , Joseph Thomas , Jingnan Liu , Tianxia Li , Timothy H Moran |
2014-09-01 |
Desat1,
CG30051,
Ilp5,
Cyp4g1,
sws,
Sec16,
Lsd-2,
Npc1b,
AP-2alpha,
ex,
Thor,
RpL27A,
Oscillin,
DIP-iota,
Npc1a,
Sirt1,
LRP1,
Egm,
CG13163,
adp,
ktub,
twz,
Atf-2,
Mtch,
Akh,
melt,
Ilp2,
Ilp3,
Aps,
Bmcp,
bmm,
SREBP,
isoQC,
Fancl,
foxo,
PKD,
Nrx-1,
hh,
Hmgcr,
Ets96B,
Lnk,
boss,
AMPKalpha,
sbb,
bgm,
Lk6,
Tor,
heph,
chico
|
| 22936248 |
Genome Res. Philippe Batut , Alexander Dobin , Charles Plessy , Piero Carninci , Thomas R Gingeras |
2013-01-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员