| Type | Description |
|---|---|
| Definition | phosphodiesterase 4D |
| Date | Results | Publications |
|---|---|---|
| 2019-05-25 12:06:00 | The mRNA expression of PDE4D was significantly increased in allergic rats, but PDE4B was not. PDE4B was mainly distributed in the cytoplasm, whereas PDE4D was mainly distributed in the cell membrane | 30628641 |
| 2018-03-03 10:18:00 | Data reveal essential roles of beta-arrestin 2 and PDE4D in a common mechanism for heterologous desensitization of cardiac beta adrenergic receptors under hormonal stimulation, which is associated with impaired cardiac function during the development of pathophysiological conditions. | 28339772 |
| 2015-11-21 10:33:00 | SIK1 serves as a part of a self-regulatory circuit to modulate insulin secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D activity. | 25918234 |
| 2015-05-16 11:24:00 | specific inhibitory PDE4D mutations can lead to the molecular pathology of acrodysostosis without hormone resistance but that the pathological phenotype may well be dependent on an over-compensatory induction of other PDE4 isoforms | 25064455 |
| 2015-03-07 11:54:00 | PDE4D9 was found to locate primarily not only in the perinuclear region of Rat-1 cells but also at the cell margins. | 24815749 |
| Type | IDs |
|---|---|
| Synonymous | DPDE3, PDE3/IVd |
| Gene |
UniProtKB-ID:
PDE4D_RAT
UniprotKB:
P14270
UniParc:
UPI0000EA37E8,
UPI000003622B,
UPI00001707C8,
UPI000002A6E1,
UPI00000E8F4A,
UPI000049E300,
UPI0000EA36E8,
UPI0000127BFA,
UPI00000E6705
EMBL:
AABR06012742,
AABR06012741,
AABR06012744,
AABR06012747,
U01285,
L27060,
AABR06012757,
AF536974,
AABR06012754,
EF102484,
AF536979,
AABR06012748,
U01278,
U09455,
AABR06012750,
U01279,
U01280,
AF031373,
AABR06012760,
AABR06012753,
U01286,
AABR06012739,
AABR06012755,
L27059,
AABR06012740,
AABR06012745,
U09456,
AABR06012749,
AABR06012738,
U01284,
AABR06012758,
AY388961,
AABR06012756,
U01287,
AABR06012751,
AABR06012759,
AABR06012743,
EF121818,
U09457,
AABR06012746,
AABR06012736,
AABR06012737,
U01283,
U01282,
AABR06012752
Ensembl:
ENSRNOG00000042536
KO:
rno:24627
|
| Nucleutide sequences |
EMBL-CDS:
ABL14108.1,
AAN10116.1,
AAN10121.1,
AAA20393.1,
AAC26969.1,
AAA18924.1,
AAB95266.1,
AAA18925.1,
AAA56857.1,
ABK97408.1,
AAA20401.1,
AAB81869.1,
AAQ90405.1
Ensembl_TRS:
ENSRNOT00000066384,
ENSRNOT00000067546
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000063446,
ENSRNOP00000062384
RefSeq:
NP_001106803.1,
NP_001106805.1,
XP_008758945.1,
NP_001106800.1,
NP_058728.1,
XP_008758944.1,
XP_008758943.1,
NP_001106799.1
|
| Others |
UniRef100:
UniRef100_P14270
UniRef90:
UniRef90_P14270
UniRef50:
UniRef50_P14270
UniGene:
Rn.95959,
Rn.163460
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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