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24626 Pde4b

24626

Pde4b

phosphodiesterase 4B

protein-coding

Rattus norvegicus

基因描述

Type Description
Definition phosphodiesterase 4B

研究结论

Date Results Publications
2019-07-20 12:57:00 PDE4B is primarily responsible for muscle proteolysis in burn injury and it, thus, constitutes a unique target for selective manipulations with drugs to control muscle cachexia. 29693432
2019-05-25 12:06:00 The mRNA expression of PDE4D was significantly increased in allergic rats, but PDE4B was not. PDE4B was mainly distributed in the cytoplasm, whereas PDE4D was mainly distributed in the cell membrane 30628641
2014-11-08 13:45:00 PDE4B mediates a crucial feedback that controls beta1 adrenergic receptor-dependent cAMP signals in a restricted subsarcolemmal domain. 24413164
2013-11-30 10:37:00 Upregulated PDE4 expression during cholestatic liver injury plays a potential pathogenic role in the development of inflammation and fibrosis. 23887098
2013-08-10 11:14:00 Acutely after spinal cord injury, PDE4B is localized to activated microglia and is absent in uninjured spinal cord or inactive microglia. 22865690

名称对应

Type IDs
Synonymous PDE4/IVb, Pde4B1, Pde4B2, Pde4B3, Pde4B4, Pde4b5, Pde4b_v1, Pde4b_v2, Pde4b_v3, Pde4b_v4
Gene
UniProtKB-ID: PDE4B_RAT
UniprotKB: P14646
UniParc: UPI000002A6D9, UPI0000127BF7, UPI000156545E, UPI0001565464, UPI0001565463
EMBL: U95748, AF202733, U01291, J04563, U01296, U01295, L27058, U01293, AF202732, M28413, U01289, U01298, U01294, U01297, BC085704, U01290, M25350
Ensembl: ENSRNOG00000005905
KO: rno:24626
Nucleutide sequences
EMBL-CDS: AAA74478.1, AAA66039.1, AAA41846.1, AAL31763.1, AAA41824.1, AAH85704.1, AAA18926.1, AAB96560.1, AAL31764.1
Ensembl_TRS: ENSRNOT00000007738
Protein sequencees
Ensembl_PRO: ENSRNOP00000007738
RefSeq: NP_058727.3
Others
UniRef100: UniRef100_P14646
UniRef90: UniRef90_Q07343
UniRef50: UniRef50_Q07343
UniGene: Rn.37733

全选

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研究热度

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