| Type | Description |
|---|---|
| Definition | ribonuclease H1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 12:55:00 | The protein-protein interaction between P54nrb and RNase H1 requires the spacer region of RNAse H1, while the P54nrb core domains are required for association with RNase H1. | 31495875 |
| 2019-06-29 11:53:00 | A second nuclease is therefore required to remove the last ribonucleotides and we demonstrate that Flap endonuclease 1 (FEN1) can execute this function in vitro. Removal of RNA primers at OriL thus depends on a two-nuclease model, which in addition to RNase H1 requires FEN1 or a FEN1-like activity. These findings define the role of RNase H1 at OriL and help to explain the pathogenic consequences of disease causing mutatio | 30102370 |
| 2019-03-16 11:12:00 | In combination with previously published in vivo data, the findings presented here suggest a model, in which R-loop processing by RNase H1 directs origin-specific initiation of DNA replication in human mitochondria. | 30605451 |
| 2018-10-27 10:39:00 | RNASEH1 gene variants associate with susceptibility/protection to T1 Diabetes in Colombia. | 29204916 |
| 2018-02-10 11:41:00 | Studies indicate that ribonuclease H1 is essential for mitochondrial DNA replication. | 27402764 |
| Type | IDs |
|---|---|
| Synonymous | H1RNA, PEOB2, RNH1 |
| Gene |
UniProtKB-ID:
RNH1_HUMAN,
B3KUD4_HUMAN,
E5KN15_HUMAN
UniprotKB:
O60930,
B3KUD4,
E5KN15
UniParc:
UPI000178E04B,
UPI00001343BC
EMBL:
HQ205111,
HQ205139,
HQ205118,
HQ205117,
CH471053,
HQ205124,
AF048995,
HQ205121,
AC108488,
HQ205142,
HQ205138,
HQ205127,
HQ205119,
HQ205137,
AF048994,
HQ205114,
HQ205131,
HQ205143,
HQ205110,
HQ205128,
HQ205108,
HQ205130,
CR541820,
HQ205109,
HQ205116,
BC002973,
AK096913,
HQ205136,
HQ205125,
HQ205134,
HQ205129,
BT019670,
AJ224117,
HQ205115,
HQ205145,
HQ205113,
HQ205122,
HQ205106,
AF039652,
HQ205135,
HQ205107,
HQ205132,
AK075490,
HQ205120,
HQ205140,
HQ205123,
HQ205144,
HQ205126,
HQ205112,
HQ205141,
HQ205133
Ensembl:
ENSG00000171865
KO:
hsa:246243
|
| Nucleutide sequences |
EMBL-CDS:
AAX82026.1,
AAV38476.1,
CAA11835.1,
AAC09261.1,
AAC78564.1,
BAG52156.1,
CAG46619.1,
AAH02973.1,
EAX01061.1,
AAC78563.1,
BAG53396.1,
ADP90597.1,
ADP90611.1,
ADP90612.1,
ADP90613.1,
ADP90574.1,
ADP90590.1,
ADP90584.1,
ADP90607.1,
ADP90598.1,
ADP90596.1,
ADP90595.1,
ADP90601.1,
ADP90604.1,
ADP90587.1,
ADP90578.1,
ADP90605.1,
ADP90600.1,
ADP90588.1,
ADP90583.1,
ADP90594.1,
ADP90582.1,
ADP90610.1,
ADP90593.1,
ADP90589.1,
ADP90603.1,
ADP90609.1,
ADP90581.1,
ADP90591.1,
ADP90579.1,
ADP90602.1,
ADP90606.1,
ADP90592.1,
ADP90608.1,
ADP90576.1,
ADP90575.1,
ADP90577.1,
ADP90585.1,
ADP90586.1,
ADP90599.1,
ADP90580.1
Ensembl_TRS:
ENST00000315212
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000313350
RefSeq:
NP_001365200.1,
NP_001365202.1,
NP_002927.2,
NP_001273763.1,
NP_001273766.1,
NP_001365201.1
|
| Others |
UniRef100:
UniRef100_B3KUD4,
UniRef100_O60930
UniRef90:
UniRef90_H2NT08,
UniRef90_O60930
UniRef50:
UniRef50_O60930
UniGene:
Hs.568006
CCDS:
CCDS1647.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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