| Type | Description |
|---|---|
| Definition | CCR4-NOT transcription complex subunit 6 like |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 12:47:00 | We show that knockdown of human XRN1, CNOT6 and ETF1 genes in HepG2 cells led to significant alteration in stability of specific mRNAs, alterations in half-life were inversely associated with transcription rates, mostly not resulting in changes in abundance | 31116665 |
| 2020-03-28 11:53:00 | Studied hepatic role in metabolic homeostasis of fibroblast growth factor 21(FGF21) and the "CCR4-NOT complex" (a multisubunit protein complex composed of "CCR4-NOT transcription complex subunit 6 like" (CNOT6L) and "CCR4-NOT transcription complex subunit 6" (CNOT6). Results show CNOT6L plays a major role in regulation FGF21 levels. | 30926667 |
| 2019-11-16 12:15:00 | Active 1-hydroxy-xanthines inhibit both isolated Caf1 (CNOT7) enzyme and human Caf1-containing complexes that also contain the second nuclease subunit Ccr4 (CNOT6L) to a similar extent, indicating that the active site of the Caf1 nuclease subunit does not undergo substantial conformational change when bound to other Ccr4-Not subunits. | 30984545 |
| 2017-05-27 10:24:00 | Structural analysis shows that all inhibitors occupy the substrate and magnesium-binding sites of CNOT6L, suggesting that inhibitors compete with both substrate and divalent magnesium ions for overlapping binding sites. | 27013054 |
| 2016-05-28 10:27:00 | Data show that CNOT6L protein-interleukin 8 (IL-8) is a signaling axis in myogenesis. | 26608607 |
| Type | IDs |
|---|---|
| Synonymous | CCR4b |
| Gene |
UniProtKB-ID:
CNO6L_HUMAN,
B4E0K8_HUMAN,
H0Y9Z5_HUMAN
UniprotKB:
Q96LI5,
B4E0K8,
H0Y9Z5
UniParc:
UPI0000D9B0B3,
UPI0000EE2CB4,
UPI0000E445DF,
UPI00017A857C
EMBL:
AK058188,
AK303417,
AC104701,
AL133112
Ensembl:
ENSG00000138767
KO:
hsa:246175
|
| Nucleutide sequences |
EMBL-CDS:
BAB71707.1,
CAB61415.1,
BAG64470.1
Ensembl_TRS:
ENST00000504123,
ENST00000512485,
ENST00000649644
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000424896,
ENSP00000425571,
ENSP00000497467
RefSeq:
NP_001374770.1,
NP_001374769.1,
XP_011530109.1,
XP_011530108.1,
NP_001374772.1,
XP_011530111.1,
NP_001374767.1,
NP_001273719.1,
NP_001374765.1,
XP_016863446.1,
NP_001374768.1,
NP_001351936.1,
NP_001374771.1,
NP_653172.2,
NP_001374766.1,
NP_001374764.1,
XP_011530110.1,
NP_001351935.1
|
| Others |
UniRef100:
UniRef100_Q96LI5,
UniRef100_B4E0K8
UniRef90:
UniRef90_I3MPI4,
UniRef90_Q96LI5
UniRef50:
UniRef50_Q8VEG6,
UniRef50_Q96LI5
UniGene:
Hs.592519
CCDS:
CCDS68731.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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