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245944 Vps54

245944

Vps54

VPS54 GARP complex subunit

protein-coding

Mus musculus

基因描述

Type Description
Definition VPS54 GARP complex subunit

研究结论

Date Results Publications
2018-12-22 10:28:00 UBPy-sorted cargo to acrosome biogenesis and effects of its derailment in a mouse model of globozoospermia, the infertile Vps54 (L967Q) mutant, are reported. 28299521
2016-07-30 10:28:00 This study demonstrated that the cerebellum is affected by neurodegenerative and inflammatory processes in the Wobbler mouse model of ALS. 26945034
2015-06-27 14:19:00 Investigation of cells derived from wobbler and Vps54 null mutant embryos demonstrates impaired retrograde transport of the Cholera-toxin B subunit to the trans-Golgi network and mis-sorting of mannose-6-phosphate receptors and cargo proteins. 23708095
2014-11-22 11:02:00 We conclude that a missense mutation in VPS54, an essential component of the Golgi-associated retrograde protein complex, not only prevents the formation of an acrosome but also initiates a cascade of metabolic abnormalities and a stress reaction. 24115398
2010-09-06 12:15:00 Severely reduced levels of mutant Vps54 and, consequently, of the whole complex underlie the phenotype of the wobbler mouse. 20615984

名称对应

Type IDs
Synonymous Hcc8, Vps54l, mSLP8, wr
Gene
UniProtKB-ID: VPS54_MOUSE, Q91ZJ4_MOUSE
UniprotKB: Q5SPW0, Q91ZJ4
UniParc: UPI0000020F2F, UPI00000E8F50, UPI0000253849
EMBL: AK077306, BC025012, AL669979, BC023474, AB052761, BC024789, AL833772, AF424699
Ensembl: ENSMUSG00000020128
KO: mmu:245944
Nucleutide sequences
EMBL-CDS: BAC53794.1, AAH25012.1, AAH23474.1, AAH24789.1, BAC36741.1, AAL24808.2
Ensembl_TRS: ENSMUST00000109578, ENSMUST00000006221
Protein sequencees
Ensembl_PRO: ENSMUSP00000006221, ENSMUSP00000105206
RefSeq: XP_011242022.1, NP_620692.3, NP_001277557.1, XP_006514762.1, XP_030101864.1
Others
UniRef100: UniRef100_Q91ZJ4, UniRef100_Q5SPW0
UniRef90: UniRef90_Q5SPW0, UniRef90_Q9P1Q0-4
UniRef50: UniRef50_Q9P1Q0, UniRef50_Q9P1Q0-4
UniGene: Mm.170103
CCDS: CCDS24463.1, CCDS70147.1

全选

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