| Type | Description |
|---|---|
| Definition | membrane metallo-endopeptidase |
| Date | Results | Publications |
|---|---|---|
| 2019-04-20 10:59:00 | Study shows that chronic intermittent hypoxia (CIH) induces changes on the expression and activity of neprilysin (NEP) in the brain of rats. Data show that CIH protocol increases the expression and activity of NEP selectively in the temporal cortex. | 29702204 |
| 2019-03-16 11:09:00 | In standard light/dark conditions, the results demonstrated an opposite daily rhythm in hypothalamus and pituitary. While the highest levels of AlaAP or enkephalinase activities were measured in hypothalamus during the dark period, they were the highest in the pituitary during the light one. | 30531704 |
| 2017-12-02 12:26:00 | hypoxia increased the expression of platelet-derived growth factor (PDGF) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells. | 27373199 |
| 2016-04-09 11:30:00 | The data obtained suggest that the increase of caspase-3 enzyme activity could affect NEP expression via proteolytic degradation of its transcription factor AICD | 26983277 |
| 2015-08-15 10:10:00 | the increased expression of NPR-C (r=-0.943 and -0.837 for mRNA and protein respectively, p<0.05) and NEP (r=-0.687 and -0.823 for mRNA and protein respectively, p<0.05) were accompanied by a signi fi cant decline in CNP. | 24189506 |
| Type | IDs |
|---|---|
| Synonymous | CD10, Nep, SFE |
| Gene |
UniProtKB-ID:
NEP_RAT
UniprotKB:
P07861
UniParc:
UPI0000142578
EMBL:
BC085753,
M15944
Ensembl:
ENSRNOG00000009514
KO:
rno:24590
|
| Nucleutide sequences |
EMBL-CDS:
AAA41116.1,
AAH85753.1
Ensembl_TRS:
ENSRNOT00000088565
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000074307
RefSeq:
XP_017446119.1,
NP_036740.1,
XP_006232499.1,
XP_017446118.1
|
| Others |
UniRef100:
UniRef100_P07861
UniRef90:
UniRef90_P08473
UniRef50:
UniRef50_P08473
UniGene:
Rn.33598
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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