| Type | Description |
|---|---|
| Definition | speedy/RINGO cell cycle regulator family member A |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 10:42:00 | This mouse model demonstrates for the first time that degradation of the cyclin-like protein Spy1 is an essential component of p53-mediated tumour suppression. Targeting cyclin-like protein activity may therefore represent a mechanism of re-sensitizing cells to important cell cycle checkpoints in a therapeutic setting. | 31829284 |
| 2017-12-02 10:10:00 | Authors demonstrate that mammalian Spy1-mediated ERK activation increases ligand-independent phosphorylation and activation of estrogen receptor alpha, correlating with a decrease in tamoxifen sensitivity. | 28423577 |
| 2017-08-12 11:52:00 | The authors find that Spy1 confers structural changes to Cdk2 that obviate the requirement of Cdk activation loop phosphorylation. | 28666995 |
| 2016-11-19 10:06:00 | CRMP1 interacted with Spy1 which would disturb the association of CRMP1 with actin and was involved in the collapse of growth cones induced by Sema3A and regeneration after sciatic nerve crush. | 25526860 |
| 2016-10-22 10:30:00 | Spy1 participates in the proliferation and apoptosis of epithelial ovarian cancer. | 26644004 |
| Type | IDs |
|---|---|
| Synonymous | RINGO3, RINGOA, SPDY1, SPY1 |
| Gene |
UniProtKB-ID:
SPDYA_HUMAN,
A0A384MTT5_HUMAN
UniprotKB:
Q5MJ70,
A0A384MTT5
UniParc:
UPI00001D7CB6,
UPI00002081C1
EMBL:
BC093005,
CH471053,
AY820304,
GQ891528,
AC097720,
AY820303
Ensembl:
ENSG00000163806
KO:
hsa:245711
|
| Nucleutide sequences |
EMBL-CDS:
AAY24014.1,
AAH93005.1,
AAW30395.1,
AAW30394.1,
EAX00526.1,
ADO22390.1
Gene_ORFName:
hCG_1783771
Ensembl_TRS:
ENST00000334056,
ENST00000379579
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000368898,
ENSP00000335628
RefSeq:
NP_001136106.1,
NP_877433.2,
NP_001008779.1
|
| Others |
UniRef100:
UniRef100_Q5MJ70
UniRef90:
UniRef90_Q5MJ70
UniRef50:
UniRef50_Q5MJ70
UniGene:
Hs.511956
CCDS:
CCDS1767.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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