| Type | Description |
|---|---|
| Definition | melanocortin 2 receptor accessory protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-07 13:01:00 | MRAP2 in paraventricular MC4R neurons controls energy intake and expenditure. | 30352741 |
| 2018-01-27 10:43:00 | MRAP2 is an important modulator of the energy homeostasis machinery that operates through the regulation of multiple GPCRs throughout the hypothalamus. | 28959025 |
| 2017-06-24 10:56:00 | Mrap2 KO mice have a significant increase in body weight, with increased fat and lean mass, but without detectable changes in food intake or energy expenditure. Transcriptomic analysis showed significantly decreased expression of Sim1, Trh, Oxt and Crh within the paraventricular nucleus of Mrap2 KO mice. Circulating levels of both high-density and low-density lipoprotein were increased in Mrap2 KO mice. | 27106110 |
| 2016-12-17 10:49:00 | show that MRAP2 significantly and specifically inhibits PKR1 signaling. | 26829592 |
| 2013-08-10 11:12:00 | Mrap2 interacts directly with melanocortin 4 receptor (Mc4r), a protein previously implicated in mammalian obesity, and it enhances Mc4r-mediated generation of the second messenger cyclic adenosine monophosphate, suggesting that alterations in Mc4r signaling may be one mechanism underlying the association between Mrap2 disruption and obesity. | 23869016 |
| Type | IDs |
|---|---|
| Synonymous | BB633055 |
| Gene |
UniProtKB-ID:
MRAP2_MOUSE
UniprotKB:
D3Z1Q2
UniParc:
UPI0000429080
EMBL:
AC168882,
AC125370
Ensembl:
ENSMUSG00000042761
KO:
mmu:244958
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000049457,
ENSMUST00000179313,
ENSMUST00000113149
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000108774,
ENSMUSP00000135904,
ENSMUSP00000046271
RefSeq:
XP_006511239.1,
XP_036010903.1,
NP_001346884.1,
NP_001094952.2,
XP_006511241.1,
XP_006511237.1,
NP_001171202.1,
XP_006511240.1,
XP_030100245.1,
XP_036010904.1,
XP_006511242.1
|
| Others |
UniRef100:
UniRef100_D3Z1Q2
UniRef90:
UniRef90_D3Z1Q2
UniRef50:
UniRef50_D3Z1Q2
UniGene:
Mm.335337
CCDS:
CCDS52878.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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