| Type | Description |
|---|---|
| Definition | PH domain and leucine rich repeat protein phosphatase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:18:00 | Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver. | 33758172 |
| 2020-10-10 12:59:00 | Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling. | 32268790 |
| 2020-05-02 12:47:00 | PHLPP2 was identified as a direct target of miR-130a-3p, and the hepatic exosome-derived miR-130a-3p could improve glucose intolerance via suppressing PHLPP2 to activate AKT-AS160-GLUT4 signaling pathway in adipocytes. | 31715176 |
| 2019-11-16 12:36:00 | PHLPP2 silencing increased the phosphorylation of glycogen synthase kinase (GSK)-3beta and promoted the nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). In addition, PHLPP2 inhibition promoted Nrf2/antioxidant response element (ARE) transcriptional activity. | 31610156 |
| 2017-12-09 12:11:00 | KCTD17, which is up-regulated in liver tissues of obese mice and patients with NAFLD, binds to phosphorylated PHLPP2 to target it for ubiquitin-mediated degradation; this increases expression of genes that regulate lipogenesis to promote hepatic steatosis. | 28859855 |
| Type | IDs |
|---|---|
| Synonymous | AI481772, C130044A18Rik, Phlppl |
| Gene |
UniProtKB-ID:
PHLP2_MOUSE,
J3QM82_MOUSE
UniprotKB:
Q8BXA7,
J3QM82
UniParc:
UPI0000D62F7E,
UPI00001E441A
EMBL:
AK048260,
AC122807,
AK048472,
BC117962,
BC117961
Ensembl:
ENSMUSG00000031732
KO:
mmu:244650
|
| Nucleutide sequences |
EMBL-CDS:
AAI17962.1,
BAC33288.1,
AAI17963.1,
BAC33347.2
Ensembl_TRS:
ENSMUST00000034175,
ENSMUST00000179721
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000034175,
ENSMUSP00000136166
RefSeq:
XP_036009935.1,
XP_030099411.1,
XP_006531073.1,
NP_001116066.2
|
| Others |
UniRef100:
UniRef100_Q8BXA7
UniRef90:
UniRef90_Q8BXA7
UniRef50:
UniRef50_Q6ZVD8
UniGene:
Mm.23494
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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