| Type | Description |
|---|---|
| Definition | microcephaly, primary autosomal recessive 1 |
| Date | Results | Publications |
|---|---|---|
| 2015-10-31 11:32:00 | MCPH1 is a bona fide tumor suppressor gene. | 25362854 |
| 2013-09-14 11:42:00 | Mcph1-deficient mice reveal a role for MCPH1 in otitis media. Expression of Mcph1 in the epithelial cells of middle ear cavities supported its involvement in the development of otitis media. | 23516444 |
| 2011-12-24 10:04:00 | MCPH1, through its function in the Chk1-Cdc25-Cdk1 pathway to couple the centrosome cycle with mitosis, is required for precise mitotic spindle orientation and thereby regulates the progenitor division mode to maintain brain size. | 21947081 |
| 2011-10-08 12:04:00 | VIP blockade induces microcephaly through Mcph1 signaling; VIP/Mcph1/Chk1 signaling is key for normal cortical development | 21737879 |
| 2011-09-03 11:39:00 | SET is an important regulator of chromosome condensation/decondensation and disruption of the MCPH1-SET interaction might be important for the pathogenesis of primary microcephaly | 21515671 |
| Type | IDs |
|---|---|
| Synonymous | 5430437K10Rik, BRIT1, D030046N04Rik, MCT, Tg(HLA-A2.1)1Enge |
| Gene |
UniProtKB-ID:
MCPH1_MOUSE
UniprotKB:
Q7TT79
UniParc:
UPI000019A66A
EMBL:
AK083572,
AY070216,
BC056924,
AK042026
Ensembl:
ENSMUSG00000039842
KO:
mmu:244329
|
| Nucleutide sequences |
EMBL-CDS:
BAC38955.2,
AAL50216.1,
AAH56924.1,
BAC31136.1
Ensembl_TRS:
ENSMUST00000039412
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000037000
RefSeq:
XP_017168280.1,
XP_030099393.1,
XP_030099392.1,
XP_011240358.1,
XP_011240360.1,
XP_036009911.1,
XP_011240361.1,
XP_017168281.1,
XP_006508853.1,
XP_011240359.1,
XP_030099391.1,
XP_036009913.1,
XP_036009916.1,
XP_006508849.1,
XP_036009912.1,
XP_036009915.1,
XP_017168277.1,
XP_030099394.1,
XP_017168278.1,
XP_017168279.1,
XP_036009914.1,
NP_775281.2
|
| Others |
UniRef100:
UniRef100_Q7TT79
UniRef90:
UniRef90_Q7TT79
UniRef50:
UniRef50_Q7TT79
UniGene:
Mm.235296
CCDS:
CCDS22124.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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