| Type | Description |
|---|---|
| Definition | MAS-related GPR, member X2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 11:53:00 | granuloma formation during intrathecal morphine infusion was associated with MrgprB2/X2. Reducing MRGPRX2 potentially blocks morphine-induced side effects, including granuloma formation. | 31484729 |
| 2020-04-25 10:36:00 | Gold chloride induces a pseudo-allergic reaction via MRGPRX2 both in vitro and in vivo. | 31076078 |
| 2019-11-02 11:44:00 | The N-methyl substitution on the side chain of these drugs played a significant role in activating MRGPRX2. | 31051313 |
| 2019-08-17 10:17:00 | this study shows that mast cell-mediated hypersensitivity to fluoroquinolone is MRGPRX2 dependent | 30856392 |
| 2019-08-03 10:23:00 | The targeting of MRGPRX2 can potentially block mivacurium-induced adverse drug effects. | 30121125 |
| Type | IDs |
|---|---|
| Synonymous | G370024M05Rik, MrgB10, Mrgprb10 |
| Gene |
UniProtKB-ID:
MRGX2_MOUSE,
Q3UFT2_MOUSE
UniprotKB:
Q3UG50,
Q3UFT2
UniParc:
UPI00001C3C8F,
UPI00005AC7AA
EMBL:
AK148121,
HG426112,
AK148319,
AC115742
Ensembl:
ENSMUSG00000074109
KO:
mmu:243978
|
| Nucleutide sequences |
EMBL-CDS:
BAE28359.1,
CDG86230.1,
BAE28478.1
Ensembl_TRS:
ENSMUST00000098433
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000127022
RefSeq:
NP_001030040.2
|
| Others |
UniRef100:
UniRef100_Q3UG50
UniRef90:
UniRef90_Q3UG50
UniRef50:
UniRef50_Q3UG50
UniGene:
Mm.333873
CCDS:
CCDS52258.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31484729 |
A Mast Cell-Specific Receptor Is Critical for Granuloma Induced by Intrathecal Morphine Infusion. J. Immunol. Tao Zhang , Rui Liu , Delu Che , Priyanka Pundir , Nan Wang , Shengli Han , Jiao Cao , Yanni Lv , Haiyan Dong , Fang Fang , Jue Wang , Pengyu Ma , Tingting Zhao , Ting Lei , Xinzhong Dong , Langchong He |
2019-10-01 | - |
| 31051313 |
Mol. Immunol. Yajing Hou , Delu Che , Di Wei , Cheng Wang , Yitong Xie , Kaining Zhang , Jiao Cao , Jia Fu , Nan Zhou , Huaizhen He |
2019-07-01 | - |
| 31076078 |
Gold induces a pseudo-allergic reaction via MRGPRX2 both in vitro and in vivo. Cell. Immunol. Yingnan Zeng , Jue Wang , Yongjing Zhang , Shuai Ge , Yuanyuan Wu , Ting Fan , Nan Wang |
2019-07-01 | - |
| 30856392 |
Mast cell-mediated hypersensitivity to fluoroquinolone is MRGPRX2 dependent. Int. Immunopharmacol. Rui Liu , Shiling Hu , Yongjing Zhang , Delu Che , Jiao Cao , Jue Wang , Tingting Zhao , Qianqian Jia , Nan Wang , Tao Zhang |
2019-05-01 | - |
| 30121125 |
Cell. Immunol. Delu Che , Jue Wang , Yuanyuan Ding , Rui Liu , Jiao Cao , Yongjing Zhang , Yajing Hou , Hongli An , Zijun Gao , Tao Zhang |
2018-10-01 | - |
| 28987593 |
MRGPRX2 is essential for sinomenine hydrochloride induced anaphylactoid reactions. Biochem. Pharmacol. Rui Liu , Delu Che , Tingting Zhao , Priyanka Pundir , Jiao Cao , Yanni Lv , Jue Wang , Pengyu Ma , Jia Fu , Nana Wang , Xiaoyang Wang , Tao Zhang , Xinzhong Dong , Langchong He |
2017-12-15 | - |
| 25517090 |
Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature Benjamin D McNeil , Priyanka Pundir , Sonya Meeker , Liang Han , Bradley J Undem , Marianna Kulka , Xinzhong Dong |
2015-03-12 |
Gt(ROSA)26Sor,
Mrgprx2,
Mrgprb2,
MRGPRX2
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 16141073 |
Antisense transcription in the mammalian transcriptome. Science S Katayama , Y Tomaru , T Kasukawa , K Waki , M Nakanishi , M Nakamura , H Nishida , C C Yap , M Suzuki , J Kawai , H Suzuki , P Carninci , Y Hayashizaki , C Wells , M Frith , T Ravasi , K C Pang , J Hallinan , J Mattick , D A Hume , L Lipovich , S Batalov , P G Engström , Y Mizuno , M A Faghihi , A Sandelin , A M Chalk , S Mottagui-Tabar , Z Liang , B Lenhard , C Wahlestedt , RIKEN Genome Exploration Research Group , Genome Science Group (Genome Network Project Core Group) , FANTOM Consortium |
2005-09-02 |
Gm14018,
Gm14964,
F630206G17Rik,
Oog3,
Notumos,
Ldlrap1,
Mdn1,
Pydc3,
9330171B17Rik,
Mfap1b,
Tmsb15b2,
Gm12802,
E430020m11rik,
Gm11335,
Gm15772,
Gm17762,
A930017K11Rik,
LOC100036513,
Gata5os,
Umad1,
Gm16982,
Gm9887,
Gm9872,
LOC100036530,
Gm9934,
Gm9913,
Gm11149,
BC028777,
Gm13999,
LOC100036540,
Gm9744,
Gm9983,
D630002J18Rik,
Gm16525,
Gm11696,
Dnajc3,
9430060I03Rik,
Gm12359,
4921516A02Rik,
Fam129c,
Gm10589,
Rsph3b,
Rnaset2a,
5430403G19Rik,
D030047H15Rik,
Gm13274,
B930046K06Rik,
Gm10862,
Gm10792,
Gm10802,
Gm10532,
G730003C15Rik,
Runx2os1,
Gm15612,
Gm10856,
Gm10857,
Gm10685,
Gm10803,
Gm10723,
F630028O10Rik,
Gm10836,
Gm10405,
Gm10513,
Gm10609,
F630201L12Rik,
4932427H20Rik,
Zfp389,
Gm10763,
Gm10062,
Gm10714,
Gm10531,
Gm10876,
Gm10750,
Gm10433,
Gm10837,
Gm10647,
Gm10648,
Gm10650,
Gm10610,
F830115B05Rik,
Gm10473,
Gm10614,
Gm10286,
G730046D07Rik,
Gm10287,
Gm10785,
Gm10183,
Gm10512,
1700061E17Rik,
Gm44113,
Gm10579,
Gm10741,
Gm10827,
Gm10522,
Gm10536,
Gm15998,
Faddos,
D130050E23Rik,
Gm10735
|
| 16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
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|---|---|---|
| {{authorIndex+1}} |
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