| Type | Description |
|---|---|
| Definition | SH3 and multiple ankyrin repeat domains 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-28 11:49:00 | SHANK1 plays a role in neocortical learning-induced dendritic spine plasticity underlying learning and normal cognition; and in mechanisms mediating abnormalities of impaired cognition. | 30053575 |
| 2018-12-01 12:24:00 | A review: Shank1 knockout mouse model for autism spectrum disorder (ASD) displays moderate impairments in (I) social behavior, (II) communication, and (III) repetitive and stereotyped patterns of behavior, together with (IV) aberrant cognitive phenotypes, consistent with the symptoms present in humans diagnosed with ASD and carrying SHANK1 deletions. | 28963042 |
| 2018-11-10 10:47:00 | Study demonstrates that SHANK1 is developmentally expressed in hippocampal neurons and glial cells. Although the specific role for this developmental expression pattern in these different cell types is not fully understood, the current study provides the first developmental cell-type-specific expression profile. | 29218848 |
| 2018-02-03 11:56:00 | Expression of SHANK genes is a key component of autism spectrum disorder-associated pathways as the protein products are enriched in the postsynaptic density (PSD) of glutamatergic neurons. | 26419918 |
| 2018-02-03 10:12:00 | The findings of this study indicated that Shank1 deletions lead to an aberrant cognitive phenotype characterized by severe impairments in object recognition memory and increased hippocampal BDNF levels, possibly due to epigenetic modifications. | 28500650 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SHAN1_MOUSE,
D3YZU5_MOUSE,
D3YZU4_MOUSE
UniprotKB:
D3YZU1,
D3YZU5,
D3YZU4
UniParc:
UPI00006057B6,
UPI0000D77B19,
UPI0000D77B1A
EMBL:
AC152939,
CO436178
Ensembl:
ENSMUSG00000038738
KO:
mmu:243961
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000107938,
ENSMUST00000107934,
ENSMUST00000107935
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000103571,
ENSMUSP00000103567,
ENSMUSP00000103568
RefSeq:
NP_001029287.1,
XP_006540934.3,
XP_030098436.1,
XP_006540933.1,
XP_006540929.1,
XP_036009003.1,
XP_006540928.1,
XP_006540937.1,
XP_006540932.1,
XP_006540938.1,
XP_006540939.1,
XP_036009006.1,
XP_006540930.1,
XP_030098435.1,
XP_030098438.1,
XP_036009004.1,
XP_006540935.1,
XP_036009005.1,
XP_006540931.1,
XP_006540927.1
|
| Others |
UniRef100:
UniRef100_D3YZU5,
UniRef100_D3YZU4,
UniRef100_D3YZU1
UniRef90:
UniRef90_Q9WV48
UniRef50:
UniRef50_Q9WV48
UniGene:
Mm.360368
CCDS:
CCDS52229.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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