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24385 Gck

24385

Gck

glucokinase

protein-coding

Rattus norvegicus

基因描述

Type Description
Definition glucokinase

研究结论

Date Results Publications
2020-07-25 11:26:00 Study in different rat models demonstrated that glucokinase (GCK)-mediated glucose phosphorylation is the rate-controlling step in insulin-stimulated hepatic glycogen synthesis in vivo under both normal and pathophysiological conditions of fatty liver-associated hepatic insulin resistance and it is controlled chiefly through GCK translocation. 32188779
2016-04-16 11:11:00 The enhancing effect of INGAP-PP on glucose-induced insulin release could be partly ascribed to its effect on glucokinase activity and glucose metabolism and is mainly mediated by the PI3K/AKT pathway. 25906449
2015-04-25 10:25:00 Arcuate nucleus glucokinase activation may represent a CNS mechanism that underlies the oft-described phenomena of the "sweet tooth" and carbohydrate craving. 25485685
2014-12-20 10:06:00 Atf3-silencing reversed ethanol-mediated Gck down-regulation and beta-cell dysfunction, followed by the amelioration of impaired glucose tolerance and insulin resistance. 25074928
2014-11-22 10:57:00 Chronic treatment with glucose kinase activators in animal models of diabetes provided sustained lowering of blood glucose. 24772484

名称对应

Type IDs
Synonymous GLK, GLUKA, RNGK2
Gene
UniProtKB-ID: HXK4_RAT, X2G6B3_RAT, Q64596_RAT
UniprotKB: P17712, X2G6B3, Q64596
UniParc: UPI000012CFAF, UPI000002AB78, UPI00000E8A93, UPI000002AB79
EMBL: CH473963, M24948, KJ026953, J04218, X53590, M24943, X53589, M24944, M58759, M24949, M24945, X53588, M24950, M25806, M30770, AC110110, M24952, M24947, M25807, M24951
Ensembl: ENSRNOG00000061527
KO: rno:24385
Nucleutide sequences
EMBL-CDS: AAA41231.1, AAA41230.1, CAA37660.1, AAA41229.1, AAA41236.1, AAA41239.1, AAA41238.1, CAA37657.1, EDM00325.1, AHN15398.1, EDM00323.1, CAA37658.1
Gene_ORFName: rCG_35874, rCG_35874
Ensembl_TRS: ENSRNOT00000086474, ENSRNOT00000086343, ENSRNOT00000080147
Protein sequencees
Ensembl_PRO: ENSRNOP00000071435, ENSRNOP00000069954, ENSRNOP00000068656
RefSeq: NP_001257778.1, NP_001257779.1, NP_036697.1, XP_006251241.1
Others
UniRef100: UniRef100_Q64596, UniRef100_P17712
UniRef90: UniRef90_Q64596, UniRef90_P35557
UniRef50: UniRef50_Q64596, UniRef50_P35557
UniGene: Rn.10447

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