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243634 Ano2

243634

Ano2

anoctamin 2

protein-coding

Mus musculus

基因描述

Type Description
Definition anoctamin 2

研究结论

Date Results Publications
2020-07-04 11:03:00 TMEM16b regulates action potential firing in lateral septum and aggression in male mice. 31320449
2020-06-06 13:35:00 Ano2/TMEM16B is a Ca2+-activated chloride channel in vagal afferents of nodose neurons and a major determinant of CCK-induced satiety, body weight control, and energy expenditure, making it a potential therapeutic target in obesity. 30843875
2020-02-08 11:29:00 Here the authors report that Ano2 knockout mice exhibit impaired anxiety-related behaviors and context-independent fear memory, thus implicating TMEM16B in anxiety modulation. 31482844
2019-11-02 10:25:00 Study provides the first in vivo evidence toward an alternative or additional role for Ano2 in the olfactory transduction cascade, where it may serve as a feedback mechanism to clamp olfactory receptor neurons spike output. 30006552
2018-08-04 10:48:00 Results of behavioral studies obtained from Ano2 (-/-) mice, a mouse line that was previously shown to lack this particular mode of ionic plasticity. The animals display motor coordination deficits that constitute a condition of mild ataxia. Moreover, motor learning is severely impaired in Ano2 (-/-) mice, suggesting cerebellar dysfunction. 28536821

名称对应

Type IDs
Synonymous BC033409, Tmem16b
Gene
UniProtKB-ID: ANO2_MOUSE
UniprotKB: Q8CFW1
UniParc: UPI0001823FDA
EMBL: BC033409, FJ384096, AK044763
Ensembl: ENSMUSG00000038115
KO: mmu:243634
Nucleutide sequences
EMBL-CDS: BAC32073.1, ACL36051.1, AAH33409.1
Ensembl_TRS: ENSMUST00000160496
Protein sequencees
Ensembl_PRO: ENSMUSP00000125303
RefSeq: NP_001351491.1, XP_006506180.1, XP_006506178.1, NP_001351492.1, XP_006506182.1, NP_705817.2
Others
UniRef100: UniRef100_Q8CFW1
UniRef90: UniRef90_Q8CFW1
UniRef50: UniRef50_Q8CFW1
UniGene: Mm.333398
CCDS: CCDS39643.2

全选

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研究热度

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