| Type | Description |
|---|---|
| Definition | hydrocarboxylic acid receptor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-28 13:16:00 | The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment. | 32071396 |
| 2020-09-12 16:03:00 | Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling. | 32669546 |
| 2020-06-27 11:04:00 | HCAR1 activation decreased miniature EPSC frequency, increased paired-pulse ratio, decreased firing frequency, modulated membrane intrinsic properties, and decreased spontaneous calcium spiking activity of primary cortical neurons. It interacts with adenosine A1, GABAB, and alpha2A-adrenergic receptors, by its Gialpha and Gibetagamma subunits. Activation downmodulates neuronal activity via presynaptic mechanisms reduci... | 30926749 |
| 2020-04-25 10:16:00 | Study examined whether HCAR1 activation in brown adipose tissue (BAT) plays a key role in regulating glucose homeostasis in mice fed a high-fat diet (HFD). Results found a sexual dimorphism in HCAR1 expression in BAT from mice fed HFD that may contribute to the development of hyperglycemia in male C57BL/6J DIO mice. | 31999787 |
| 2020-04-04 12:43:00 | Loss of GPR81 expression is associated with Ischemic Retinopathy. | 31220454 |
| Type | IDs |
|---|---|
| Synonymous | Gpr81 |
| Gene |
UniProtKB-ID:
HCAR1_MOUSE,
E9PZR8_MOUSE,
A0A4Y1JWM1_MOUSE
UniprotKB:
Q8C131,
E9PZR8,
A0A4Y1JWM1
UniParc:
UPI0001B8381A,
UPI0000027316
EMBL:
EU809460,
AC122753,
AC129582,
BC141305,
AK029064,
KU285433
Ensembl:
ENSMUSG00000049241
KO:
mmu:243270
|
| Nucleutide sequences |
EMBL-CDS:
AAI41306.1,
BAC26273.1,
ACJ03846.1,
APT70315.1
Ensembl_TRS:
ENSMUST00000164267
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000129280
RefSeq:
NP_780729.3
|
| Others |
UniRef100:
UniRef100_Q8C131
UniRef90:
UniRef90_Q8C131
UniRef50:
UniRef50_Q9BXC0
UniGene:
Mm.33362
CCDS:
CCDS19669.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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